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The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma
Article first published online: 21 AUG 2009
DOI: 10.1002/cncr.24627
Copyright © 2009 American Cancer Society
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How to Cite
Agrawal, S., Kane, J. M., Guadagnolo, B. A., Kraybill, W. G. and Ballo, M. T. (2009), The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma. Cancer, 115: 5836–5844. doi: 10.1002/cncr.24627
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Publication History
- Issue published online: 2 DEC 2009
- Article first published online: 21 AUG 2009
- Manuscript Accepted: 5 MAY 2009
- Manuscript Revised: 27 APR 2009
- Manuscript Received: 5 JAN 2009
References
- 1, , . Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases. Arch Surg. 1989; 124: 1051-1055.
- 2, , , , . Axillary dissection in melanoma. Prognostic variables in node-positive patients. Ann Surg. 1990; 212: 125-131.
- 3, , , , . Improved long-term survival after lymphadenectomy of melanoma metastatic to regional nodes. Analysis of prognostic factors in 1134 patients from the John Wayne Cancer Clinic. Ann Surg. 1991; 214: 491-499; discussion 499-501.
- 4, , . Prognostic factors in patients with melanoma metastatic to axillary or inguinal lymph nodes. A multivariate analysis. Ann Surg. 1991; 214: 627-636.
- 5, , , et al. The prognosis of patients with stage III melanoma. Prospective long-term study of 286 patients of the Fachklinik Hornheide. Cancer. 1993; 71: 1239-1246.
- 6, , , , , . Prognostic variables for patients with stage III malignant melanoma. Eur J Surg. 2000; 166: 233-239.Direct Link:
- 7, , , , . Long-term survival in 2505 patients with melanoma with regional lymph node metastasis. Ann Surg. 2002; 235: 879-887.
- 8, , , , , . Nodal basin recurrence following lymph node dissection for melanoma: implications for adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2000; 46: 467-474.
- 9, , , et al. Risk factors for nodal recurrence after lymphadenectomy for melanoma. Ann Surg Oncol. 2001; 8: 109-115.
- 10, , , et al. Experience with 998 cutaneous melanomas of the head and neck over 30 years. Am J Surg. 1991; 162: 310-314.
- 11, , . Morbidity, mortality and local recurrence following regional node dissection for melanoma. Br J Surg. 1986; 73: 906-908.
- 12, , , . Local control following therapeutic nodal dissection for melanoma. J Surg Oncol. 1993; 54: 18-22.
- 13, , , et al. Adjuvant irradiation for axillary metastases from malignant melanoma. Int J Radiat Oncol Biol Phys. 2002; 52: 964-972.
- 14, , , et al. Adjuvant irradiation for cervical lymph node metastases from melanoma. Cancer. 2003; 97: 1789-1796.
- 15, , , et al. A critical assessment of adjuvant radiotherapy for inguinal lymph node metastases from melanoma. Ann Surg Oncol. 2004; 11: 1079-1084.
- 16, , , et al. Combined-modality therapy for patients with regional nodal metastases from melanoma. Int J Radiat Oncol Biol Phys. 2006; 64: 106-113.
- 17, , , et al. A prospective phase II study of adjuvant postoperative radiation therapy following nodal surgery in malignant melanoma—Trans Tasman Radiation Oncology Group (TROG) Study 96.06. Radiother Oncol. 2006; 81: 136-142.
- 18, , , . Axillary node dissection in malignant melanoma: results and complications. Surgery. 1990; 108: 10-17.
- 19, , . Prognosis and surgical management of patients with palpable inguinal lymph node metastases from melanoma. Br J Surg. 2000; 87: 892-901.
- 20, , , , . Positive iliac and obturator nodes in melanoma: survival and prognostic factors. Ann Surg Oncol. 1999; 6: 255-262.
- 21, , , . Axillary node dissection in malignant melanoma. Am J Surg. 1991; 162: 202-207.
- 22, , , et al. Prognostic value of size of lymph node metastases in patients with cutaneous melanoma. J Clin Oncol. 1995; 13: 2361-2368.
- 23, , , . Superficial inguinal and radical ilioinguinal lymph node dissection in patients with palpable melanoma metastases to the groin—an analysis of survival and local recurrence. Acta Oncol. 2001; 40: 72-78.
- 24, , , . Lymph node dissection for clinically evident lymph node metastases of malignant melanoma. Eur J Surg Oncol. 2002; 28: 424-430.
- 25, , , . Melanoma with metastasis to regional axillary or inguinal lymph nodes: prognostic factors and results of surgical treatment in 714 patients. South Med J. 1988; 81: 5-9.
- 26, , , , . Implications of microscopic satellites of the primary and extracapsular lymph node spread in patients with high-risk melanoma: pathologic corollary of Eastern Cooperative Oncology Group Trial E1690. J Clin Oncol. 2002; 20: 2053-2057.
- 27, , , . Judging the therapeutic value of lymph node dissections for melanoma. J Am Coll Surg. 2000; 191: 16-22; discussion 22-23.
- 28, , , , , , et al. Factors prognostic for survival in patients with malignant melanoma spread to the regional lymph nodes. Ann Surg. 1982; 196: 69-75.
- 29, , , et al. Postoperative radiotherapy for cutaneous melanoma of the head and neck region. Int J Radiat Oncol Biol Phys. 1994; 30: 795-798.
- 30, , , . Prevention of local recurrence after surgical debulking of nodal and subcutaneous melanoma deposits by hypofractionated radiation. Ann Surg Oncol. 2000; 7: 680-684.
- 31, , , , . Elective radiation therapy for high-risk malignant melanomas. Cancer J. 2001; 7: 498-502.
- 32, , , et al. Adjuvant radiotherapy following neck dissection and parotidectomy for metastatic malignant melanoma. Head Neck. 1997; 19: 589-594.
- 33, , , . Nodal radiation therapy for metastatic melanoma. Int J Radiat Oncol Biol Phys. 1999; 44: 1065-1069.
- 34, , , et al. Role of radiation therapy in the management of cutaneous malignant melanoma. Am J Clin Oncol. 1999; 22: 184-186.
- 35, , , et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med. 1997; 337: 949-955.
- 36, , , , , . Postoperative radiotherapy for stage II or III nonsmall-cell lung cancer using the Surveillance, Epidemiology, and End Results database. J Clin Oncol. 2006; 24: 2998-3006.
- 37, , , et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004; 350: 1945-1952.

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