Racial disparities for uterine corpus tumors
Changes in clinical characteristics and treatment over time
Article first published online: 22 OCT 2009
Copyright © 2010 American Cancer Society
Volume 116, Issue 1, page 256, 1 January 2010
How to Cite
Grant, W. B. (2010), Racial disparities for uterine corpus tumors. Cancer, 116: 256. doi: 10.1002/cncr.24689
- Issue published online: 11 JAN 2010
- Article first published online: 22 OCT 2009
The recent paper by Wright et al 1 found that black women were 60% more likely to die from their corpus uteri tumors than white women when matched for other prognostic variables.
A factor overlooked in this study was the role of vitamin D. Solar ultraviolet B (UVB) and vitamin D have been found inversely correlated with many types of cancer, including corpus uteri. In an ecological study of cancer mortality rates for white Americans, which included indices for various cancer risk factors, 14 types of cancer including uterine corpus and breast cancer were found inversely correlated with summertime solar UVB doses. 2 Solar UVB was also found inversely correlated with breast and several other types of cancer for black Americans.3 There is sufficient evidence regarding the mechanisms and from 1 randomized controlled trial that the vitamin D-cancer link can be considered causal.4
Because breast and corpus uteri cancer mortality rates have similar geographic variations in the United States, 2 the study of disparities in breast cancer survival can be investigated to consider whether differences in vitamin D status might affect corpus uteri cancer survival rates. In a recent publication,5 it was noted that black Americans have much higher rates of hypovitaminosis D prevalence; that those diagnosed with breast, colon, or prostate cancer or Hodgkin lymphoma in summer or fall in Norway have better 36-month survival rates than those diagnosed in winter or spring; and that a randomized controlled trial involving postmenopausal women living in Nebraska found a 35% reduction in all-cancer incidence for those taking 1100 IU/day of vitamin D.5
CONFLICT OF INTEREST DISCLOSURES
The author receives funding from the UV Foundation (McLean, Va), the Vitamin D Society (Canada), the Sunlight Research Forum (Veldhoven, the Netherlands), and Bio-Tech-Pharmacal (Fayetteville, Ark).
- 1Racial disparities for uterine corpus tumors: changes in clinical characteristics and treatment over time. Cancer. 2009; 115: 1276-1285., , , et al.
- 2The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res. 2006; 26: 2687-2699., .
- 3Lower vitamin-D production from solar ultraviolet-B irradiance may explain some differences in cancer survival rates. J Natl Med Assoc. 2006; 98: 357-364..
- 4How strong is the evidence that solar ultraviolet B and vitamin D reduce the risk of cancer? An examination using Hill's criteria for causality. Dermatoendocrinol. 2009; 1: 17-24..
- 5Differences in vitamin D status may explain black-white differences in breast cancer survival rates. J Natl Med Assoc. 2008; 100: 1040..
William B. Grant PhD*, * SUNARC, San Francisco, California.