Fax: (949) 824-1343
Original Article
You have full text access to this OnlineOpen article
Nonsteroidal anti-inflammatory drugs†
Effects on mortality after colorectal cancer diagnosis
Article first published online: 13 OCT 2009
DOI: 10.1002/cncr.24705
Copyright © 2009 American Cancer Society
Additional Information
How to Cite
Zell, J. A., Ziogas, A., Bernstein, L., Clarke, C. A., Deapen, D., Largent, J. A., Neuhausen, S. L., Stram, D. O., Ursin, G. and Anton-Culver, H. (2009), Nonsteroidal anti-inflammatory drugs. Cancer, 115: 5662–5671. doi: 10.1002/cncr.24705
- †
Presented in part at the American Society of Preventive Oncology Annual Meeting, Bethesda, Maryland, March 16–18, 2008.
Publication History
- Issue published online: 2 DEC 2009
- Article first published online: 13 OCT 2009
- Manuscript Accepted: 20 APR 2009
- Manuscript Revised: 14 APR 2009
- Manuscript Received: 4 FEB 2009
Funded by
- National Cancer Institute. Grant Numbers: R01 CA77398, R25 CA85771
- National Institute of Environmental Health Sciences. Grant Number: P30 ES 07,048
- California Breast Cancer Research Fund. Grant Number: 97-10,500
References
- 1, , , , , . Cancer statistics, 2007. CA Cancer J Clin. 2007; 57: 43-66.Direct Link:
- 2, , . Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development. Cancer Res. 1987; 47: 5340-5346.
- 3, , , et al. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res. 1996; 56: 2556-2560.
- 4, . Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin. Gastroenterology. 1998; 114: 873-877.
- 5, , , , . The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. Cancer Res. 2000; 60: 5040-5044.
- 6. Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. Environ Mol Mutagen. 2004; 44: 26-35.Direct Link:
- 7, , . Sulindac corrects defective apoptosis and suppresses azoxymethane-induced colonic oncogenesis in p53 knockout mice. Int J Cancer. 2005; 116: 870-875.Direct Link:
- 8, , , et al. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer. 2007; 120: 459-468.Direct Link:
- 9, , , et al. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology. 1991; 101: 635-639.
- 10, , , et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med. 1993; 328: 1313-1316.
- 11, , , , . Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell-proliferation in patients with familial adenomatous polyposis. Br J Surg. 1993; 80: 1618-1619.Direct Link:
- 12, , , et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 2000; 342: 1946-1952.
- 13, , , , , . A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. Clin Cancer Res. 2003; 9: 4756-4760.
- 14, , , et al. A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med. 2003; 348: 891-899.
- 15, , , et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med. 2003; 348: 883-890.
- 16, . Nonsteroidal anti-inflammatory drugs and aspirin for the prevention of colorectal adenomas and cancer: a systematic review. Dis Colon Rectum. 2004; 47: 665-673.
- 17, , , et al. A prospective study of aspirin use and the risk for colorectal adenoma. Ann Intern Med. 2004; 140: 157-166.
- 18, , , et al. Statins and the risk of colorectal cancer. N Engl J Med. 2005; 352: 2184-2192.
- 19, . Chemoprevention of colorectal cancer. Dis Colon Rectum. 2006; 49: 113-124.
- 20, , , , , . Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA. 2005; 294: 914-923.
- 21, , , . Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2006; 15: 1785-1790.
- 22, , . Chemoprevention of gastrointestinal malignancies with nonsteroidal anti inflammatory drugs: a review. Cancer. 2002; 94: 950-963.Direct Link:
- 23, , , , , . A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence. J Natl Cancer Inst. 2007; 99: 608-615.
- 24, , , , , . Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med. 1994; 121: 241-246.
- 25, , , et al. Influence of regular aspirin use on survival for patients with stage III colon cancer: findings from Intergroup trial CALGB 89803. J Clin Oncol. 2005; 23( 16 suppl pt I): 3530.
- 26, , , et al. High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States). Cancer Causes Control. 2002; 13: 625-635.
- 27, , , , , . Cancer in California: 1988-1999. Sacramento, CA: California Department of Health Services, Cancer Surveillance Section; 2001.
- 28, , , , , . International Classification of Diseases for Oncology. 3rd ed. Geneva, Switzerland: World Health Organization; 2000.
- 29, , , et al. Recent diet and breast cancer risk: the California Teachers Study (USA). Cancer Causes Control. 2002; 13: 407-415.
- 30, , , , . SEER Summary Staging Manual—2000: Codes and Coding Instructions. Bethesda, Md: National Cancer Institute; 2001.
- 31, , , , , . Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994; 107: 1183-1188.
- 32, , , et al. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest. 1997; 99: 2254-2259.
- 33, , . Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med. 2007; 356: 2131-2142.
- 34, , , . A phase I study of 5-fluorouracil, leucovorin, and celecoxib in patients with incurable colorectal cancer. Prostaglandins Other Lipid Mediat. 2005; 75: 169-172.
- 35, . COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol. 2005; 23: 2840-2855.
- 36. Celecoxib with chemotherapy in colorectal cancer. Oncology (Williston Park). 2002; 16( 4 suppl 3): 17-21.
- 37, , , et al. Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol. 2001; 2: 544-551.
- 38, , , et al. Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med. 2006; 355: 873-884.
- 39, , , et al. Effect of celecoxib on cardiovascular events and blood pressure in 2 trials for the prevention of colorectal adenomas. Circulation. 2006; 114: 1028-1035.
- 40, , , et al. Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force. Ann Intern Med. 2007; 146: 376-389.
- 41, , , , , . A prospective study of family history and the risk of colorectal cancer. N Engl J Med. 1994; 331: 1669-1674.
- 42, . A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol. 2001; 96: 2992-3003.Direct Link:
- 43, , , . Colon cancer: a review of the epidemiology. Epidemiol Rev. 1993; 15: 499-545.
- 44, . Family history of cancer and colon cancer risk: the Utah Population Database. J Natl Cancer Inst. 1994; 86: 1618-1626.
- 45, , . The effect of family history of cancer, religion, parity and migrant status on survival in colorectal cancer. Eur J Cancer. 1992; 28: 1484-1487.
- 46, . The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995; 24: 888-896.
- 47, , , , . Family history and survival after colorectal cancer diagnosis. Cancer. 2008; 112: 1222-1229.Direct Link:
- 48Registry Committee, Japanese Research Society for Cancer of the Colon and Rectum. Clinical and pathological analyses of patients with a family history of colorectal cancer. Jpn J Clin Oncol. 1993; 23: 342-349.
- 49, , , et al. Association of family history with cancer recurrence and survival among patients with stage III colon cancer. JAMA. 2008; 299: 2515-2523.
- 50, , , . Survival after colorectal cancer diagnosis is associated with colorectal cancer family history. Cancer Epidemiol Biomarkers Prev. 2008; 17: 3134-3140.

1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470)