Original Article

You have full text access to this OnlineOpen article

A phase 2 study of platinum and gemcitabine in patients with advanced salivary gland cancer

A Trial of the NCIC Clinical Trials Group

  1. Scott A. Laurie MD1,†,*,
  2. Lillian L. Siu MD2,
  3. Eric Winquist MD, MSc3,
  4. Andrew Maksymiuk MD4,
  5. Erica L. Harnett MSc5,
  6. Wendy Walsh BSc5,
  7. Dongsheng Tu PhD5,
  8. Wendy R. Parulekar MD5

Article first published online: 18 NOV 2009

DOI: 10.1002/cncr.24745

Issue

Cancer

Cancer

Volume 116, Issue 2, pages 362–368, 15 January 2010

Additional Information

How to Cite

Laurie, S. A., Siu, L. L., Winquist, E., Maksymiuk, A., Harnett, E. L., Walsh, W., Tu, D. and Parulekar, W. R. (2010), A phase 2 study of platinum and gemcitabine in patients with advanced salivary gland cancer. Cancer, 116: 362–368. doi: 10.1002/cncr.24745

Author Information

  1. 1

    Department of Medical Oncology, Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada

  2. 2

    Department of Medical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada

  3. 3

    Department of Medical Oncology, London Health Sciences Centre, London, Ontario, Canada

  4. 4

    Department of Medical Oncology, CancerCare Manitoba, Winnipeg, Manitoba, Canada

  5. 5

    NCIC Clinical Trials Group, Queens University, Kingston, Ontario, Canada

  1. †

    Fax: (613) 247-3511

*Medical Oncology, Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Ottawa ON K1H 8L6 Canada

Publication History

  1. Issue published online: 20 JAN 2010
  2. Article first published online: 18 NOV 2009
  3. Manuscript Accepted: 14 MAY 2009
  4. Manuscript Received: 13 MAR 2009

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (147K)

REFERENCES

  • 1
    Barnes L, Everson JW, Reichart P, Sidransky D. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon, France: IARC Press; 2005.
  • 2
    Spiro RH, Huvos AG. Stage means more than grade in adenoid cystic carcinoma. Am J Surg. 1992; 164: 623-628.
  • 3
    Van Der Waal JE, Becking AG, Snow GB, Van Der Waal I. Distant metastases of adenoid cystic carcinoma of the salivary glands and the value of diagnostic examinations during follow-up. Head Neck. 2002; 24: 779-783.
    Direct Link:
  • 4
    Spiro RH. Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg. 1997; 174: 495-498.
  • 5
    Terhaard CHJ, Lubsen H, Van der Tweel I, et al. Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases and overall survival: results of the Dutch Head and Neck Oncology Cooperative Group. Head Neck. 2004; 26: 681-693.
    Direct Link:
  • 6
    Laurie SA, Licitra L. Systemic therapy in the palliative management of advanced salivary gland cancers. J Clin Oncol. 2006; 24: 2673-2678.
  • 7
    Agulnik M, Siu L. An update on the systemic therapy of malignant salivary gland cancers: role of chemotherapy and molecular targeted agents. Curr Med Chem Anticancer Agents. 2004; 4: 543-51.
  • 8
    Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med. 2002; 346: 92-98.
  • 9
    von der Maase H, Sengelov L, Roberts JT, et al. Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol. 2005; 23: 4602-4608.
  • 10
    Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst. 2000; 92: 205-216.
  • 11
    Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials. 1989; 10: 1-10.
  • 12
    Laurie SA, Su YB, Pfister DG. Chemotherapy in the management of metastatic adenoid cystic carcinoma: a systematic review. ASCO Annual Meeting Proceedings. J Clin Oncol. 2005; 23: 5581.
  • 13
    Mattox DE, Von Hoff DD, Balcerzak SP. Southwest Oncology Group study of mitoxantrone for treatment of patients with advanced adenoid cystic carcinoma of the head and neck. Invest New Drugs. 1990; 8: 105-107.
  • 14
    Verweij J, de Mulder PHM, de Graeff A, et al. Phase II study on mitoxantrone in adenoid cystic carcinomas of the head and neck. Ann Oncol. 1996; 7: 867-869.
  • 15
    Vermorken JB, Verweij J, de Mulder PHM, et al. Epirubicin in patients with advanced or recurrent adenoid cystic carcinoma of the head and neck: a phase II study of the EORTC Head and Neck Cancer Cooperative Group. Ann Oncol. 1993; 4: 785-788.
  • 16
    Gilbert J, Li Y, Pinto HA, et al. Phase II trial of Taxol in salivary gland malignancies (E1394): a trial of the Eastern Cooperative Oncology Group. Head Neck. 2006; 28: 197-204.
    Direct Link:
  • 17
    Airoldi M, Pedani F, Succo G, et al. Phase II randomized trial comparing vinorelbine versus vinorelbine plus cisplatin in patients with recurrent salivary gland malignancies. Cancer. 2001; 91: 541-547.
    Direct Link:
  • 18
    Licitra L, Marchini S, Spinazze S, et al. Cisplatin in advanced salivary gland cancer. Cancer. 1991; 68: 1874-1877.
    Direct Link:
  • 19
    van Herpen CML, Locati LD, Buter J, et al. Phase II study on gemcitabine in recurrent and/or metastatic adenoid cystic carcinoma of the head and neck (EORTC 24982). Eur J Cancer. 2008; 44: 2542-2545.
  • 20
    Haddad R, Posner MR. Palliative chemotherapy in patients with salivary gland neoplasms and preliminary reports of 2 recent phase II studies with trastuzumab and gemcitabine. Clin Adv Hematol Oncol. 2003; 1: 226-228.
  • 21
    Airoldi M, Fornari G, Fedani F, et al. Paclitaxel and carboplatin for recurrent salivary gland malignancies. Anticancer Res. 2000; 20: 3781-3784.
  • 22
    Soto Parra H, Cavina R, Latteri F, et al. Three-week versus four-week schedule of cisplatin and gemcitabine: results of a randomized phase II study. Ann Oncol. 2002; 13: 1080-1086.
  • 23
    Shepherd FA, Abratt R, Crino L, et al. The influence of gemcitabine and cisplatin schedule on response and survival in advanced non-small cell lung cancer. Lung Cancer. 2000; 30: 117-125.
View Full Article (HTML) Get PDF (147K)