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Generational risks for cancers not related to tobacco, screening, or treatment in the United States
Article first published online: 5 JAN 2010
Copyright © 2010 American Cancer Society
Volume 116, Issue 4, pages 940–948, 15 February 2010
How to Cite
Han, Y.-Y., Davis, D. L., Weissfeld, J. L. and Dinse, G. E. (2010), Generational risks for cancers not related to tobacco, screening, or treatment in the United States. Cancer, 116: 940–948. doi: 10.1002/cncr.24747
- Issue published online: 2 FEB 2010
- Article first published online: 5 JAN 2010
- Manuscript Accepted: 11 MAY 2009
- Manuscript Revised: 16 APR 2009
- Manuscript Received: 29 JAN 2009
- generational risk;
- cancer trends;
- Surveillance, Epidemiology, and End Results;
- age-period-cohort model;
- cancer incidence;
- cancer mortality;
- occupational cancer;
- environmental cancer
To assess trends in cancer, the authors evaluated the risk of 1 generation compared with that 25 years earlier (generational risk) for 3 groupings of cancers: those related to tobacco; those that reflect advances in screening or treatment; and a residual category of all other cancers.
In individuals ages 20 years to 84 years, age-period-cohort models were used to summarize time trends in terms of generational risk and average annual percentage change for US cancer incidence (1975-2004) and mortality (1970-2004) rates associated with these 3 cancer groupings.
Adult white men today developed 16% fewer tobacco-related cancers and had 21% fewer deaths because of those cancers than their fathers' generation, whereas adult white women experienced increases of 28% and 19%, respectively, relative to their mothers. The incidence of commonly screened cancers rose 74% in men and 10% in women, whereas mortality fell 25% in men and 31% in women. For cancers that have not been linked chiefly to tobacco or screening, the incidence was 34% and 23% higher in white men and white women, respectively, than in their parents' generation 25 years earlier. Mortality in this residual category decreased 14% in men and 18% in women. Results among blacks were qualitatively similar to those among whites.
Despite declining overall cancer death rates, adults are experiencing increased incidence of cancers that are not associated with tobacco or screening relative to their parents. Future research should examine whether similar patterns are exhibited in other modern nations and should identify population-wide avoidable risks that could account for unexplained increases in these residual cancers. Cancer 2010. © 2010 American Cancer Society.