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Supplement
Three methods assessing red marrow dosimetry in lymphoma patients treated with radioimmunotherapy†
Article first published online: 2 FEB 2010
DOI: 10.1002/cncr.24797
Copyright © 2010 American Cancer Society
Issue
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Cancer
Supplement: Cancer Therapy With Antibodies and Immunoconjugates, Supplement to Cancer
Volume 116, Issue Supplement 4, pages 1093–1100, 15 February 2010
Additional Information
How to Cite
Ferrer, L., Kraeber-Bodéré, F., Bodet-Milin, C., Rousseau, C., Gouill, S. L., Wegener, W. A., Goldenberg, D. M. and Bardiès, M. (2010), Three methods assessing red marrow dosimetry in lymphoma patients treated with radioimmunotherapy. Cancer, 116: 1093–1100. doi: 10.1002/cncr.24797
- †
The articles in this supplement were presented at the “12th Conference on Cancer Therapy with Antibodies and Immunoconjugates,” in Parsippany, New Jersey, October 16-18, 2008.
- ‡
Fax: (011) 33 240 67 97 36
Publication History
- Issue published online: 2 FEB 2010
- Article first published online: 2 FEB 2010
- Manuscript Revised: 21 OCT 2009
- Manuscript Received: 30 JUN 2009
REFERENCES
- 1, . Advances in cancer therapy with radiolabeled monoclonal antibodies. Q J Nucl Med Mol Imaging. 2006; 50: 248-264.
- 2. Radioimmunotherapy, a new breakthrough in the treatment of follicular non-Hodgkin's lymphoma: the European perspective. Cancer Biother Radiopharm. 2006; 21: 1-4.
- 3, , , et al. Targeting, dosimetry, and radioimmunotherapy of B-cell lymphomas with iodine-131-labeled LL2 monoclonal antibody. J Clin Oncol. 1991; 9: 548-564.
- 4, , , et al. Treatment of non-Hodgkin's lymphoma with radiolabeled murine, chimeric, or humanized LL2, an anti-CD22 monoclonal antibody. Cancer Res. 1995; 55: 5899s-5907s.
- 5, , , et al. Pharmacokinetics, dosimetry and initial therapeutic results with 131I- and 111In-/90Y-labeled humanized LL2 anti-CD22 monoclonal antibody in patients with relapsed/refractory non-Hodgkin's lymphoma (NHL). Clin Cancer Res. 1999; 5: 3292s-3303s.
- 6, , , et al. Radioimmunotherapy of non-Hodgkin's lymphoma with 90Y-DOTA humanized anti- CD22 IgG (90Y-epratuzumab): do tumor targeting and dosimetry predict therapeutic response? J Nucl Med. 2003; 44: 2000-2018.
- 7, , , et al. Dose-fractionated radioimmunotherapy in non-Hodgkin's lymphoma using DOTA-conjugated, 90Y-radiolabeled, humanized anti-CD22 monoclonal antibody, epratuzumab. Clin Cancer Res. 2005; 11: 5215-5222.
- 8, , , , . 90Y-DOTA-epratuzumab: An agent for radioimmunotherapy of non-Hodgkin's lymphoma. J Nucl Med. 2003; 44: 77-84.
- 9, , , et al. Bone marrow dosimetry and toxicity for radioimmunotherapy. Antibodies Immunoconjugates Radioimmunopharm. 1990; 3: 213-233.
- 10, , , , . Practical determination of patient-specific marrow dose using radioactivity concentration in blood and body. J Nucl Med. 1999; 40: 2102-2106.
- 11. Bone marrow dosimetry for radioimmunotherapy: theoretical considerations. J Nucl Med. 1993; 34: 689-694.
- 12, , , et al. Red marrow radiation dose adjustment using plasma FLT3-L cytokine levels: Improved correlations between hematologic toxicity and bone marrow dose for radioimmunotherapy patients. J Nucl Med. 2003; 44: 67-76.
- 13, . Available at: http://www.gnuplot. info. Accessed February 18, 2009.
- 14, , , . An ImageJ plugin to create WB TAC using CT scanner. Eur. J Nucl Med. 2007; 34( suppl): S198.
- 15, , , , , . Correction of photon attenuation and collimator response for a body-contouring spect/ct imaging system. J Nucl Med. 2005; 46: 868-877.
- 16, , , et al. User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. Neuroimage. 2006; 31: 1116-1128.
- 17, , , , . Practical method for position-dependent compton-scatter correction in single photon emission ct. IEEE Trans Med Imaging. 1991; 10: 408-412.
- 18, , . Pyramid approach to subpixel registration based on intensity. IEEE Trans Image Process. 1998; 7: 27-41.
- 19, , , , , . Sacral scintigraphy for bone marrow dosimetry in radioimmunotherapy. Int J Rad Appl Instrum B. 1989; 16: 553-559.
- 20, , , et al. Improved prediction of myelotoxicity using a patient-specific imaging dose estimate for non-marrow-targeting y-antibody therapy. J Nucl Med. 2002; 43: 1245-1253.
- 21, , . Using the S tables of MIRD Pamphlet 11. J Nucl Med. 1977; 18: 747.
- 22, , , , Goldenberg DM. Estimates of red marrow dose by sacral scintigraphy in radioimmunotherapy patients having non-Hodgkin's lymphoma and diffuse bone marrow uptake. Cancer Res. 1995; 55: 5827s-5831s.
- 23. Establishing a clinically meaningful predictive model of hematologic toxicity in nonmyeloablative targeted radiotherapy: practical aspects and limitations of red marrow dosimetry. Cancer Biother Radiopharm. 2005; 20: 126-140.
- 24, , , et al. Prediction of myelotoxicity using radiation doses to marrow from body, blood and marrow sources. J Nucl Med. 1997; 38: 1374-1378.
- 25, , , et al. Imaging for improved prediction of myelotoxicity after radioimmunotherapy. Cancer. 1997; 80: 2558s-2566s.
- 26, , , . A method to correct for radioactivity in large vessels that overlap the spine in imaging-based marrow dosimetry of lumbar vertebrae. J Nucl Med. 2008; 49: 279-284.
- 27, , . A CT assisted method for absolute quantitation of internal radioactivity. Med Phys. 1996; 23: 1919-1928.
- 28, , , et al. MIRD pamphlet no. 20: The effect of model assumptions on kidney dosimetry and response–implications for radionuclide therapy. J Nucl Med. 2008; 49: 1884-1899.

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