The first 2 authors equally contributed to this article.
Genetic alterations between primary head and neck squamous cell carcinoma and recurrence after radiotherapy†
Recurrence, genetically related cancer, or second primary?
Article first published online: 19 JAN 2010
Copyright © 2010 American Cancer Society
Volume 116, Issue 5, pages 1291–1297, 1 March 2010
How to Cite
Deganello, A., Franchi, A., Sardi, I., Pignataro, L., Leemans, C. R. and Gallo, O. (2010), Genetic alterations between primary head and neck squamous cell carcinoma and recurrence after radiotherapy. Cancer, 116: 1291–1297. doi: 10.1002/cncr.24854
The authors thank Jacopo Scala, MD, for his help with the layout of figures and tables.
- Issue published online: 18 FEB 2010
- Article first published online: 19 JAN 2010
- Manuscript Accepted: 2 JUL 2009
- Manuscript Revised: 9 JUN 2009
- Manuscript Received: 1 MAR 2009
- head and neck squamous cell carcinoma;
- local recurrence;
- microsatellite instability;
- second field tumor;
- minimal residual disease
In the attempt to characterize the genetic bases of recurrent head and neck squamous cell carcinoma (HNSCC) after radiotherapy (RT), the authors compared the molecular profiles of primary tumors and recurrences.
TP53 gene status and instability at 10 microsatellite markers were determined in pre-RT lesions and corresponding local recurrences in a series of 16 HNSCCs.
Eight (50%) HNSCCs showed both TP53 and microsatellite instability (MSI) status concordance in pre- and postirradiation biopsies; 3 (18.7%) showed discordance of both TP53 and MSI status; and finally 5 (31.2%) had discordance at only 1 genetic test. Accordingly, the authors interpreted as true recurrence the 8 concordant cases, and as true second primary malignancies the 3 discordant ones. In the remaining 5 cases with partial DNA correspondence, the exact nature of the new lesion only partially related to the original cancer is a matter of discussion. Patients showing the same mutations among pre- and post-RT HNSCCs had a longer disease-free interval (DFI) and better survival than those showing discordant genetic features (log-rank test, P = .0045).
Post-RT recurrent HNSCCs are genetically heterogeneous. The genetic characterization of the recurrence, especially in those cases with a particularly short DFI showing partially discordant mutations, might have a useful clinical relevance in the restaging process. Cancer 2010. © 2010 American Cancer Society.