Fax: (415) 353-2941
Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients
Article first published online: 5 JAN 2010
Copyright © 2010 American Cancer Society
Volume 116, Issue 5, pages 1358–1366, 1 March 2010
How to Cite
Han, S. J., Yang, I., Ahn, B. J., Otero, J. J., Tihan, T., McDermott, M. W., Berger, M. S., Prados, M. D. and Parsa, A. T. (2010), Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients. Cancer, 116: 1358–1366. doi: 10.1002/cncr.24857
- Issue published online: 18 FEB 2010
- Article first published online: 5 JAN 2010
- Manuscript Accepted: 6 JUL 2009
- Manuscript Revised: 16 JUN 2009
- Manuscript Received: 30 APR 2009
- primary gliosarcoma;
- clinical subtype;
- clinical outcome;
- treatment modalities
Primary gliosarcoma (PGS) is a rare central nervous system tumor with limited experience reported in the literature. In the current study, the authors present a modern series of confirmed PGS cases treated in the era of magnetic resonance imaging (MRI), after the accepted glioblastoma management of resection, radiation, and temozolomide.
Using a retrospective review, patients with confirmed PGS were identified (1996-2008). Cases were determined to be PGS by central pathology review using the 2007 World Health Organization criteria. Extensive chart review was performed to gather clinical and pathologic data on these cases.
All but 1 patient had undergone a preoperative MRI, with 1 patient receiving a computed tomography scan due to a cardiac pacemaker. A total of 10 patients received radiotherapy with concurrent and adjuvant temozolomide chemotherapy, and 8 patients received radiotherapy alone or in combination with other chemotherapeutic agents. In 2 patients, the history of adjuvant treatment could not be confirmed. The overall median survival was 13.9 months (range, 2.2-22.9 months). Patients with gliosarcomas resembling meningioma were found to have a significantly prolonged median survival compared with patients harboring gliosarcoma resembling glioblastoma multiforme (16 months vs 9.6 months; P = .011). However, no difference in survival was noted between patients who received concurrent radiotherapy and temozolomide compared with those who did not (10.4 months vs 13.9 months; P = .946).
The results of the current study support previous hypotheses that there are 2 distinct types of PGS. The type mimicking the appearance of a meningioma appears to carry a significantly more favorable prognosis, most likely due to an increased chance at achieving macroscopic total resection. Cancer 2010. © 2010 American Cancer Society.