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A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck
Article first published online: 24 MAR 2010
Copyright © 2010 American Cancer Society
Volume 116, Issue 12, pages 2984–2992, 15 June 2010
How to Cite
Wei, S., Liu, Z., Zhao, H., Niu, J., Wang, L.-E., El-Naggar, A. K., Sturgis, E. M. and Wei, Q. (2010), A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. Cancer, 116: 2984–2992. doi: 10.1002/cncr.25058
- Issue published online: 11 JUN 2010
- Article first published online: 24 MAR 2010
- Manuscript Accepted: 21 SEP 2009
- Manuscript Revised: 30 JUL 2009
- Manuscript Received: 4 MAY 2009
- genetic variant;
- genetic susceptibility;
- head and neck cancer;
- molecular epidemiology
The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [GA]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [CG]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).
Multivariate logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). False-positive report probabilities (FPRPs) also were calculated for significant findings.
The ADH7 A92G GG and combined CG + GG genotypes were associated with a decreased risk of SCCHN (GG: adjusted OR, 0.32; 95% CI, 0.13-0.82; CG + GG: adjusted OR, 0.74; 95% CI, 0.59-0.94; FPRP, .098) compared with the CC genotype. This association was also evident in subgroups of older patients (aged >57 years), men, former smokers, patients with oral cancer, and patients with N) lymph node status (P < .05 for all); however, such associations were not observed for the ADH1B R48H SNP.
The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations. Cancer 2010. © 2010 American Cancer Society.