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Findings from a population-based national sample
Article first published online: 24 MAY 2010
Published 2010 American Cancer Society
Volume 116, Issue 15, pages 3712–3721, 1 August 2010
How to Cite
Dowling, E., Yabroff, K. R., Mariotto, A., McNeel, T., Zeruto, C. and Buckman, D. (2010), Burden of illness in adult survivors of childhood cancers. Cancer, 116: 3712–3721. doi: 10.1002/cncr.25141
Presented in part at the 33rd Annual Meeting of the American Society of Preventive Oncology (ASPO), March 8, 2009, Tampa, Florida.
This article is a US government work and, as such, is in the public domain in the United States of America.
- Issue published online: 20 JUL 2010
- Article first published online: 24 MAY 2010
- Manuscript Accepted: 9 NOV 2009
- Manuscript Revised: 19 OCT 2009
- Manuscript Received: 28 MAY 2009
- childhood cancer;
- health limitations;
- long-term survivors
The number of adult survivors of childhood cancer in the United States is increasing because of effective treatments and improved survival. The purpose of this study was to use a national, population-based sample to estimate the burden of illness in adult survivors of childhood cancer.
A total of 410 adult survivors of childhood cancer and 294,641 individuals without cancer were identified from multiple years of the National Health Interview Survey. Multiple measures of burden, general health, and lost productivity were compared using multivariate regression analyses including: logistic, polytomous logit, proportional odds, and linear models.
Controlling for the effects of age, sex, race/ethnicity, and survey year, adult survivors of childhood cancer reported poorer outcomes across the majority of general health measures and productivity measures than individuals without cancer. Survivors were more likely to report their health status as fair or poor (24.3% vs 10.9%; P < .001); having any health limitation in any way (12.9% vs 3.4%; P < .001); being unable to work because of health problems (20.9% vs 6.3%; P < .001); and being limited in the amount/kind of work because of health problems (30.9% vs 10.6%; P < .001). When categorized by time since diagnosis, cancer survivors had poor health outcomes in every time interval, with the greatest limitations in the initial 4 years after diagnosis and 30 or more years after diagnosis.
Across multiple measures, adult survivors of childhood cancers have poorer health outcomes and more health limitations than similar individuals without cancer. Cancer 2010. Published 2010 by the American Cancer Society.