Reply to decreased cancer survival in individuals separated at time of diagnosis: Critical period for cancer pathophysiology?
Article first published online: 4 OCT 2010
Copyright © 2010 American Cancer Society
Volume 116, Issue 23, page 5564, 1 December 2010
How to Cite
Sprehn, G. C., Chambers, J. E. and Johnstone, P. A. S. (2010), Reply to decreased cancer survival in individuals separated at time of diagnosis: Critical period for cancer pathophysiology?. Cancer, 116: 5564. doi: 10.1002/cncr.25270
- Issue published online: 23 NOV 2010
- Article first published online: 4 OCT 2010
We appreciate Johnson and Master's refined statistical analysis addressing cancer-specific survival, which also incorporated additional important covariates. We note that these additional analyses are consistent with our overall findings. We agree further research is needed to examine the biological basis of these differences in survival. Prospective studies would permit collection of immune biomarkers and measures of psychosocial stress/support at time of diagnosis and at periodic, follow-up intervals. Such data will be important to confirm causal pathways relating marital status and survival.
Gwen C. Sprehn PhD*, Joanna E. Chambers MD*, Peter A. S. Johnstone MD*, * Department of Neurology Indiana University School of Medicine Indianapolis, Indiana.