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Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer
Version of Record online: 22 JUL 2010
Copyright © 2010 American Cancer Society
Volume 116, Issue 21, pages 5047–5053, 1 November 2010
How to Cite
Parashar, B., Patel, P., Monni, S., Singh, P., Sood, N., Trichter, S., Sabbas, A., Wernicke, A. G., Nori, D. and Chao, K. S. C. (2010), Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer. Cancer, 116: 5047–5053. doi: 10.1002/cncr.25441
- Issue online: 22 JUL 2010
- Version of Record online: 22 JUL 2010
- Manuscript Accepted: 21 APR 2010
- Manuscript Revised: 19 MAR 2010
- Manuscript Received: 16 JAN 2010
The objective of this study was to compare the outcomes of patients who underwent wedge resection plus intraoperative brachytherapy versus patients who received stereotactic body radiotherapy (SBRT) for single malignant lung nodules.
A retrospective chart review included 55 patients who were treated for single lung nodules, and 47 of those patients who had adequate information were chosen for the current analysis. Twenty-five patients with single malignant lung nodules received SBRT. Twenty-two patients underwent limited surgical resection plus radioactive seed implantation for solitary malignant lung nodules.
Univariate statistical analysis demonstrated a significance difference only for age in the 2 groups: The mean age in the radioactive seed group (66.6 years) was statistically significantly different from the mean of the age in the SBRT group (75.9 years; 2-sided P = .04). No significant differences were observed between the 2 groups in terms of local control, distant metastasis, survival, or toxicity.
The current results demonstrated comparable efficacy in outcome and toxicity between surgical resection with radioactive seed implantation and SBRT for the treatment of single malignant lung nodules in patients who were not candidates for lobectomy/pneumonectomy. Cancer 2010. © 2010 American Cancer Society.