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Short duration of sleep increases risk of colorectal adenoma

  1. Cheryl L. Thompson PhD1,2,3,4,
  2. Emma K. Larkin PhD2,3,5,
  3. Sanjay Patel MD3,4,5,6,
  4. Nathan A. Berger MD3,4,6,
  5. Susan Redline MD2,3,4,5,
  6. Li Li MD, PhD1,2,3,4,†,*

Article first published online: 8 OCT 2010

DOI: 10.1002/cncr.25507

Issue

Cancer

Cancer

Volume 117, Issue 4, pages 841–847, 15 February 2011

Additional Information

How to Cite

Thompson, C. L., Larkin, E. K., Patel, S., Berger, N. A., Redline, S. and Li, L. (2011), Short duration of sleep increases risk of colorectal adenoma. Cancer, 117: 841–847. doi: 10.1002/cncr.25507

Author Information

  1. 1

    Department of Family Medicine, Case Western Reserve University, Cleveland, Ohio

  2. 2

    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio

  3. 3

    Case Center for Transdisciplinary Research on Energetics and Cancer, Case Western Reserve University, Cleveland, Ohio

  4. 4

    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio

  5. 5

    Center for Clinical Investigation, Case Western Reserve University, Cleveland, Ohio

  6. 6

    Department of Medicine, Case Western Reserve University, Cleveland, Ohio

  1. †

    Fax: (216) 368-4348

*Department of Family Medicine-Research Division, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106-7136

  1. †

    Fax: (216) 368-4348

Publication History

  1. Issue published online: 3 FEB 2011
  2. Article first published online: 8 OCT 2010
  3. Manuscript Accepted: 7 JUN 2010
  4. Manuscript Revised: 2 JUN 2010
  5. Manuscript Received: 5 APR 2010

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Keywords:

  • sleep duration;
  • quality of sleep;
  • colorectal adenoma;
  • Pittsburgh Sleep Quality Index

Abstract

BACKGROUND:

Short duration and poor quality of sleep have been associated with increased risks of obesity, cardiovascular disease, diabetes mellitus, and total mortality. However, few studies have investigated their associations with risk of colorectal neoplasia.

METHODS:

In a screening colonoscopy-based case-control study, the Pittsburg Sleep Quality Index (PSQI) was administered to 1240 study participants before colonoscopy.

RESULTS:

Three hundred thirty-eight (27.3%) of the participants were diagnosed with incident colorectal adenomas. Although there was no appreciable difference in the overall PSQI score between cases and adenoma-free controls (5.32 vs 5.11; P = .37), the authors found a statistically significant association of colorectal adenoma with the PSQI component 3, which corresponds to sleep duration (P = .02). Cases were more likely to average less than 6 hours of sleep per night (28.9% vs 22.1% in controls, P = .01). In multivariate regression analysis adjusted for age, gender, race, smoking, family history of colorectal cancer, and waist-to-hip ratio, individuals averaging less than 6 hours per night had an almost 50% increase in risk of colorectal adenomas (OR = 1.47; CI = 1.05-2.06, P for trend = .02) as compared with individuals sleeping at least 7 hours per night. Cases were also more likely to report being diagnosed with sleep apnea (9.8% vs 6.5%, P = .05) and more likely to have worked alternate shifts (54.0% vs 46.1%, P = .01), although these differences were not significant in multivariate models.

CONCLUSIONS:

Shorter duration of sleep significantly increases risk of colorectal adenomas. The authors' results suggest sleep duration as a novel risk factor for colorectal neoplasia. Cancer 2011. © 2010 American Cancer Society.

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