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Increased risk of severe depression in male partners of women with breast cancer†
Version of Record online: 27 SEP 2010
Copyright © 2010 American Cancer Society
Volume 116, Issue 23, pages 5527–5534, 1 December 2010
How to Cite
Nakaya, N., Saito-Nakaya, K., Bidstrup, P. E., Dalton, S. O., Frederiksen, K., Steding-Jessen, M., Uchitomi, Y. and Johansen, C. (2010), Increased risk of severe depression in male partners of women with breast cancer. Cancer, 116: 5527–5534. doi: 10.1002/cncr.25534
We thank Visti B. Larsen and Aslak H. Poulsen of the Institute of Cancer Epidemiology, Danish Cancer Society, for their assistance with the statistical analyses.
- Issue online: 23 NOV 2010
- Version of Record online: 27 SEP 2010
- Manuscript Accepted: 14 JUN 2010
- Manuscript Revised: 3 JUN 2010
- Manuscript Received: 19 FEB 2010
- affective disorder;
- breast cancer;
- cohort study;
A few small studies published to date have suggested that major psychosocial problems develop in the partners of cancer patients; however, to the authors' knowledge, no studies to date have addressed their risk for severe depression. In a retrospective cohort study, the risk for hospitalization with an affective disorder of the male partners of women with breast cancer was investigated, using unbiased, nationwide, population-based information.
Followed were 1,162,596 men born between 1925 and 1973 who were aged ≥30 years at study entry, resided in Denmark between 1994 and 2006, had no history of hospitalization for an affective disorder, and had lived continuously with the same partner for at least 5 years. A Cox regression analysis included detailed clinical information regarding the diagnosis and treatment of breast cancer and on annually updated socioeconomic and health-related indicators obtained from national administrative and disease registers.
During the 13 years of follow-up, breast cancer was diagnosed in the partners of 20,538 men. On multivariable analysis, men whose partner was diagnosed with breast cancer were found to be at an increased risk of being hospitalized with an affective disorder (hazards ratio, 1.39; 95%confidence interval, 1.20-1.61), with a dose-response pattern for the severity of breast cancer. Furthermore, men whose partner died after breast cancer had a significant, 3.6-fold increase in risk for an affective disorder when compared with men whose partner survived breast cancer.
The results of the current study supported the hypothesis that men whose partner had breast cancer were at an increased risk for hospitalization with an affective disorder. Cancer 2010. © 2010 American Cancer Society.