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Original Article
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Analysis of pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy and subsequent use of adjuvant radiation in a national cohort
Article first published online: 24 AUG 2010
DOI: 10.1002/cncr.25561
Copyright © 2010 American Cancer Society
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How to Cite
Schreiber, D., Rineer, J., Yu, J. B., Olsheski, M., Nwokedi, E., Schwartz, D., Choi, K. and Rotman, M. (2010), Analysis of pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy and subsequent use of adjuvant radiation in a national cohort. Cancer, 116: 5757–5766. doi: 10.1002/cncr.25561
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Publication History
- Issue published online: 3 DEC 2010
- Article first published online: 24 AUG 2010
- Manuscript Accepted: 7 JUL 2010
- Manuscript Revised: 5 JUL 2010
- Manuscript Received: 11 MAY 2010
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Keywords:
- prostate cancer;
- radical prostatectomy;
- radiation;
- Surveillance, Epidemiology, and End Results program;
- adjuvant radiation
Abstract
BACKGROUND:
The Surveillance, Epidemiology, and End Results database was analyzed to explore the pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy as well as the use of adjuvant radiation in this population.
METHODS:
Identified were patients from 2004 to 2006 with clinically staged T1c-2cNx-0M0 prostate adenocarcinoma who underwent radical prostatectomy. All patients had complete clinical and pathologic data. The use of postoperative radiation was recorded. Logistic regression analysis was performed to identify unadjusted and adjusted predictors for extraprostatic disease or positive surgical margins and for adjuvant radiation use.
RESULTS:
A total of 35,642 patients were identified. For those patients with Gleason 7 (4 + 3) and a prostate-specific antigen (PSA) level of ≥10.1 ng/mL or Gleason 8 to 10 with any PSA level, the rate of organ-confined disease with negative surgical margins was found to be <50%. Of those with indications for adjuvant radiation, 11.1% received the treatment.
CONCLUSIONS:
This large population-based study detailed the risk of extraprostatic extension and positive surgical margins in a broad setting across multiple regions and communities, as well as the use of adjuvant radiation for these patients. As of 2006, 11.1% of patients who had indications for adjuvant radiation received this treatment, providing a useful baseline for future patterns of care studies. Cancer 2010. © 2010 American Cancer Society.