These results were presented as a poster abstract at the American Society of Clinical Oncology Annual Meeting, Orlando, Florida, May 20, 2009.
Original Article
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Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome†
Article first published online: 8 NOV 2010
DOI: 10.1002/cncr.25598
Copyright © 2010 American Cancer Society
Additional Information
How to Cite
Bello, C., Yu, D., Komrokji, R. S., Zhu, W., Wetzstein, G. A., List, A. F. and Lancet, J. E. (2011), Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome. Cancer, 117: 1463–1469. doi: 10.1002/cncr.25598
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Publication History
- Issue published online: 18 MAR 2011
- Article first published online: 8 NOV 2010
- Manuscript Accepted: 20 JUL 2010
- Manuscript Revised: 8 JUL 2010
- Manuscript Received: 11 JAN 2010
REFERENCES
- 1, , Acute myeloid leukemia. N Engl J Med. 1999; 341: 1051-1062.
- 2Surveillance, Epidemiology, and End Results Program. Acute Myeloid Leukemia Incidence for 2000-2004. Bethesda, MD: National Cancer Institute, Division of Cancer Control and Population Sciences, Surveillance Research Program, Cancer Statistics Branch; 2007. Available at: www.seer.cancer.gov Accessed November 2009.
- 3The therapy of relapsed acute leukaemia in adults. Blood Rev. 2004; 18: 39-63.
- 4, , , et al. Age and acute myeloid leukemia. Blood. 2006; 107: 3481-3485.
- 5, , , et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome. Cancer. 2006; 106: 1090-1098.Direct Link:
- 6, , , et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 Trial. Blood. 1998; 92: 2322-2333.
- 7, , , et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood. 2001; 98: 1312-1320.
- 8, , , et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group study. Blood. 2000; 96: 4075-4083.
- 9, , Acute myelogenous leukemia and aging: clinical interactions. Hematol Oncol Clin North Am. 2000; 14: 251-267.
- 10, , , et al. On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group. J Clin Oncol. 1989; 7: 1268-1274.
- 11, , , et al. A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490). Blood. 1995; 86: 457-462.
- 12, , , et al. Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome. Cancer. 2007; 109: 265-273.Direct Link:
- 13, , , et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol. 2002; 20: 2429-2440.
- 14, , , et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med. 2006; 355: 1456-1465.
- 15, , , et al. Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B. Blood. 1981; 58: 1203-1212.
- 16, , , et al. World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC; 2008.
- 17, , , et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002; 100: 4325-4336.
- 18, , , et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. Blood. 2000; 96: 3671-3674.
- 19, , , , Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines. Blood. 2009; 113: 659-667.
- 20Role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia. Leukemia. 1996; 10: 937-942.
- 21, , Demethylation of the human MDR1 5-region accompanies activation of P-glycoprotein expression in a HL60 multidrug resistant subline. Somat Cell Mol Genet. 1997; 23: 391-400.
- 22, , , et al. Maintenance of hypomethylation status and preferential expression of exogenous human MDR1/PGY1 gene in mouse L cells by YAC mediated transfer. Somat Cell Mol Genet. 1997; 23: 259-274.
- 23, , , et al. Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance. Clin Cancer Res. 1997; 3: 2025-2032.

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