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Pulmonary tuberculosis increases the risk of lung cancer
A population-based cohort study
Article first published online: 30 SEP 2010
Copyright © 2010 American Cancer Society
Volume 117, Issue 3, pages 618–624, 1 February 2011
How to Cite
Wu, C.-Y., Hu, H.-Y., Pu, C.-Y., Huang, N., Shen, H.-C., Li, C.-P. and Chou, Y.-J. (2011), Pulmonary tuberculosis increases the risk of lung cancer. Cancer, 117: 618–624. doi: 10.1002/cncr.25616
- Issue published online: 20 JAN 2011
- Article first published online: 30 SEP 2010
- Manuscript Accepted: 3 AUG 2010
- Manuscript Revised: 24 JUL 2010
- Manuscript Received: 19 MAY 2010
- lung cancer;
- cohort study;
The possible effect of pulmonary tuberculosis (TB) on subsequent lung cancer development has been suspected, but the evidence remains inconsistent. The purpose of this study was to perform a nationwide population-based cohort study to investigate the risk of lung cancer after pulmonary TB infection.
This nationwide population-based cohort study was based on data obtained from the Taiwan National Health Insurance Database. In total, 5657 TB patients and 23,984 controls matched for age and sex were recruited for the study from 1997 to 2008.
The incidence rate of lung cancer (269 of 100,000 person-years) was significantly higher in the pulmonary TB patients than that in controls (153 of 100,000 person-years) (incidence rate ratio [IRR], 1.76; 95% confidence interval [CI], 1.33-2.32; P < .001). Compared with the controls, the IRRs of lung cancer in the TB cohort were 1.98 at 2 to 4 years, 1.42 at 5 to 7 years, and 1.59 at 8 to 12 years after TB infections. The multivariate Cox proportional hazards model revealed pulmonary TB infections (hazard ratio [HR], 1.64; 95% CI, 1.24-2.15; P < .001) and chronic obstructive pulmonary disease (HR, 1.09; 95% CI, 1.03-1.14; P = .002) to be independent risk factors for lung cancer.
Pulmonary infection with TB is associated with an increased risk of lung cancer. Cancer 2011. © 2010 American Cancer Society.