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Effectiveness of population-based service screening with mammography for women ages 40 to 49 years

Evaluation of the Swedish Mammography Screening in Young Women (SCRY) cohort

  1. Barbro Numan Hellquist MSc1,†,*,
  2. Stephen W. Duffy MSc2,
  3. Shahin Abdsaleh MD, PhD3,
  4. Lena Björneld RN4,
  5. Pál Bordás MD5,
  6. László Tabár MD, PhD6,
  7. Bedrich Viták MD, PhD7,
  8. Sophia Zackrisson MD, PhD8,
  9. Lennarth Nyström PhD9,
  10. Håkan Jonsson PhD1

Article first published online: 29 SEP 2010

DOI: 10.1002/cncr.25650

Issue

Cancer

Cancer

Volume 117, Issue 4, pages 714–722, 15 February 2011

Additional Information

How to Cite

Hellquist, B. N., Duffy, S. W., Abdsaleh, S., Björneld, L., Bordás, P., Tabár, L., Viták, B., Zackrisson, S., Nyström, L. and Jonsson, H. (2011), Effectiveness of population-based service screening with mammography for women ages 40 to 49 years. Cancer, 117: 714–722. doi: 10.1002/cncr.25650

Author Information

  1. 1

    Department of Radiation Sciences, Umeå University, Umeå, Sweden

  2. 2

    Cancer Research UK, Department of Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

  3. 3

    Department of Medical Imaging, Uppsala University Hospital, Uppsala, Sweden

  4. 4

    Department of Radiology, Sahlgrenska University Hospital, Sahlgrenska, Sweden

  5. 5

    Norrbotten Mammography Screening Program, Department of Radiology, Sunderby Hospital, Sunderby, Sweden

  6. 6

    Department of Mammography, Falun Central Hospital, Falun, Sweden

  7. 7

    Mammography Department, Linköping University Hospital, Linköping, Sweden

  8. 8

    Department of Clinical Sciences in Malmö, Diagnostic Radiology, Lund University, Lund, Sweden

  9. 9

    Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

  1. †

    Fax: (011) 46 90 12 74 64

*Department of Radiation Sciences, Umeå University, Onkologiskt Centrum, Norrlands Universitetssjukhus, 901 85 Umeå, Sweden

  1. †

    Fax: (011) 46 90 12 74 64

Publication History

  1. Issue published online: 3 FEB 2011
  2. Article first published online: 29 SEP 2010
  3. Manuscript Accepted: 10 AUG 2010
  4. Manuscript Revised: 16 JUL 2010
  5. Manuscript Received: 26 APR 2010

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Keywords:

  • mammography;
  • screening;
  • breast cancer;
  • mortality

Abstract

BACKGROUND:

The effectiveness of mammography screening for women ages 40 to 49 years still is questioned, and few studies of the effectiveness of service screening for this age group have been conducted.

METHODS:

Breast cancer mortality was compared between women who were invited to service screening at ages 40 to 49 years (study group) and women in the same age group who were not invited during 1986 to 2005 (control group). Together, these women comprise the Mammography Screening of Young Women (SCRY) cohort, which includes all Swedish counties. A prescreening period was defined to facilitate a comparison of mortality in the absence of screening. The outcome measure was refined mortality, ie, breast cancer death for women who were diagnosed during follow-up at ages 40 to 49 years. Relative risks (RRs) with 95% confidence intervals (CIs) were estimated.

RESULTS:

There was no significant difference in breast cancer mortality during the prescreening period. During the study period, there were 803 breast cancer deaths in the study group (7.3 million person-years) and 1238 breast cancer deaths in the control group (8.8 million person-years). The average follow-up was 16 years. The estimated RR for women who were invited to screening was 0.74 (95% CI, 0.66-0.83), and the RR for women who attended screening was 0.71 (95% CI, 0.62-0.80).

CONCLUSIONS:

In this comprehensive study, mammography screening for women ages 40 to 49 years was efficient for reducing breast cancer mortality. Cancer 2011. © 2010 American Cancer Society.

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