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Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors†

  1. Brent J. Small PhD1,2,‡,*,
  2. Kerri Sharp Rawson MS1,
  3. Erin Walsh MS3,
  4. Heather S. L. Jim PhD2,
  5. Tiffany F. Hughes PhD4,
  6. Lindsay Iser MA1,
  7. Michael A. Andrykowski PhD3,
  8. Paul B. Jacobsen PhD2,5

Article first published online: 8 NOV 2010

DOI: 10.1002/cncr.25685

Issue

Cancer

Cancer

Volume 117, Issue 7, pages 1369–1376, 1 April 2011

Additional Information

How to Cite

Small, B. J., Rawson, K. S., Walsh, E., Jim, H. S. L., Hughes, T. F., Iser, L., Andrykowski, M. A. and Jacobsen, P. B. (2011), Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors. Cancer, 117: 1369–1376. doi: 10.1002/cncr.25685

Author Information

  1. 1

    School of Aging Studies, University of South Florida, Tampa, Florida

  2. 2

    Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center, Tampa, Florida

  3. 3

    Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, Kentucky

  4. 4

    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania

  5. 5

    Department of Psychology, University of South Florida, Tampa, Florida

  1. ‡

    Fax: (813) 974-9754

*School of Aging Studies, University of South Florida, 4202 E. Fowler Avenue, MHC1300, Tampa, FL 33647

  1. †

    The impact of cancer treatment on cognitive performance is an important quality-of-life outcome for cancer survivors. In this study, the authors demonstrated that breast cancer survivors who were treated with chemotherapy were at the greatest risk of cognitive impairment if they carried the catechol-O-methyltransferase Val gene.

Publication History

  1. Issue published online: 18 MAR 2011
  2. Article first published online: 8 NOV 2010
  3. Manuscript Accepted: 30 AUG 2010
  4. Manuscript Revised: 11 AUG 2010
  5. Manuscript Received: 5 MAY 2010

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