See referenced original articles on pages 1687-96, 1697-703, and 1711-20, this issue.
Melanoma's deadly march to the brain†
By what route, and can it be stopped?
Article first published online: 10 NOV 2010
Copyright © 2010 American Cancer Society
Volume 117, Issue 8, pages 1560–1563, 15 April 2011
How to Cite
Othus, M., Moon, J. and Margolin, K. (2011), Melanoma's deadly march to the brain. Cancer, 117: 1560–1563. doi: 10.1002/cncr.25716
- Issue published online: 6 APR 2011
- Article first published online: 10 NOV 2010
- Manuscript Revised: 23 SEP 2010
- Manuscript Accepted: 23 SEP 2010
- Manuscript Received: 30 AUG 2010
The 3 articles reviewed in this issue of Cancer add to and update previously reported experience regarding the prognosis of melanoma patients diagnosed with brain metastases, but do not answer the important question of identifying which patients diagnosed with early melanoma will go on to develop this complication that most frequently determines the outcome in metastatic melanoma and how and when to best intervene therapeutically. If clinicians wish to use retrospective databases to help improve outcomes for these patients, then better biologic discriminators, based on careful clinico-pathologic correlational observations, need to be incorporated and then validated in large datasets to define useful prognostic subsets.