N.M, P.J.S., K.C.W., O.W.B., J.L., and C.R.F. designed the study; P.J.S., N.M., and K.C.W. collected data and performed the statistical analyses; P.J.S., A.N., R.S., O.W.B., J.L., K.C.W., and C.R.F. analyzed and interpreted the data and wrote the paper.
Racial differences in the presentation and outcomes of diffuse large B-cell lymphoma in the United States†
Article first published online: 22 DEC 2010
Copyright © 2010 American Cancer Society
Volume 117, Issue 11, pages 2530–2540, 1 June 2011
How to Cite
Shenoy, P. J., Malik, N., Nooka, A., Sinha, R., Ward, K. C., Brawley, O. W., Lipscomb, J. and Flowers, C. R. (2011), Racial differences in the presentation and outcomes of diffuse large B-cell lymphoma in the United States. Cancer, 117: 2530–2540. doi: 10.1002/cncr.25765
- Issue published online: 19 MAY 2011
- Article first published online: 22 DEC 2010
- Manuscript Accepted: 5 OCT 2010
- Manuscript Revised: 4 OCT 2010
- Manuscript Received: 17 AUG 2010
- diffuse large B-cell lymphoma;
- End Results program;
Diffuse large B-cell lymphoma (DLBCL) is often cured with standard chemoimmunotherapy, but there is great heterogeneity in presentation and outcomes.
By using Surveillance, Epidemiology, and End Results (SEER) data from 13 registries across the United States, the authors examined differences in incidence and survival for DLBCL by race. International Classification of Diseases for Oncology, third edition histology codes 9678, 9679, 9680, and 9684 were used to identify cases.
From 1992 to 2007, 38,522 cases of DLBCL were recorded in SEER. Sixty-five percent of black patients compared with 37% of white patients presented at age ≤60 years, 52% of blacks compared with 44% of whites presented with stage III/IV disease, and 31% of black versus 24% of white patients presented with B symptoms (all P < .001). Although survival improved by era of diagnosis for all races (log rank P < .001), 2-year relative survival rates were better for women than men (61% vs 58%, P < .001) and white than black patients (60% vs 50%, P < .001). Black race, male sex, age at diagnosis >60, advanced stage, and B symptoms at diagnosis were predictors of worse survival (P < .001).
Black patients with DLBCL in the United States present at younger age, more advanced stage, and have inferior survival. Epidemiological studies that examine the biological variants of DLBCL in concert with race are needed to elucidate the etiology of these disparities. Cancer 2011;. © 2010 American Cancer Society.