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The role of technetium-99m methoxyisobutyl isonitrile scintigraphy in predicting the therapeutic effect of chemotherapy against nasopharyngeal carcinoma
Article first published online: 14 DEC 2010
Copyright © 2010 American Cancer Society
Volume 117, Issue 11, pages 2435–2441, 1 June 2011
How to Cite
Wang, X. S., Zhang, Y. J., Liu, X. L., Zhou, Z. R., Hu, C. S. and Eisbruch, A. (2011), The role of technetium-99m methoxyisobutyl isonitrile scintigraphy in predicting the therapeutic effect of chemotherapy against nasopharyngeal carcinoma. Cancer, 117: 2435–2441. doi: 10.1002/cncr.25802
- Issue published online: 19 MAY 2011
- Article first published online: 14 DEC 2010
- Manuscript Accepted: 28 OCT 2010
- Manuscript Revised: 14 OCT 2010
- Manuscript Received: 1 SEP 2010
- nasopharyngeal carcinoma;
- induction chemotherapy;
- technetium-99m methoxyisobutyl isonitrile
The authors prospectively evaluated the correlation between technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) accumulation in tumors and response to induction chemotherapy in patients with nasopharyngeal carcinoma (NPC).
Eighty-six patients with locally advanced NPC underwent single-photon emission computed tomography 15 minutes after an intravenous injection of 740 megabecquerels (20 mCi) 99mTc-MIBI before chemotherapy. The tumor uptake ratio (TUR) was calculated. Two weeks after the second cycle of combined chemotherapy with 5-fluorouracil (5-FU) and cisplatin (DDP), the tumor response rate was evaluated. The correlation between 99mTc-MIBI accumulation in tumors and response to chemotherapy with 5-FU/DDP was examined.
Positive accumulation of 99mTc-MIBI in tumors was observed in 76 patients (88.4%). The tumor response was a complete response (CR) in 8 patients, a partial response (PR) in 68 patients, stable disease (SD) in 9 patients, and progressive disease (PD) in 1 patient. The response rate (CR and PR) to 5-FU/DDP chemotherapy in patients who had positive 99mTc-MIBI accumulation (tumor uptake ratio [TUR] >1.1) was higher than that in patients who had negative 99mTc-MIBI accumulation (TUR ≤1.1; 98.7% vs 10%; P < .001).
Patients with negative 99mTc-MIBI accumulation were resistant to 5-FU/DDP chemotherapy. 99mTc-MIBI imaging in patients with NPC was capable of predicting tumor response to chemotherapy with 5-FU/DDP and can help in the selection of patients for induction chemotherapy. Cancer 2011. © 2010 American Cancer Society.