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Keywords:

  • cancer genomes;
  • human genome;
  • somatic mutations;
  • cancer genetics;
  • pediatric cancer;
  • adolescent cancer;
  • young adult cancer;
  • pharmacogenomics;
  • pharmacogenetics;
  • whole genome sequencing

Abstract

This mini-review describes the rapid changes in genome technologies that are leading to comprehensive views of genetic alterations in cancer, and presents high-level thoughts on ways to accelerate translation into clinical medicine. Issues that are more relevant to children, adolescents, and young adult patients with cancer are highlighted. Cancer 2011;117(10 suppl):2262–7. © 2011 American Cancer Society.