Review Article

Current trends and emerging future of indocyanine green usage in surgery and oncology

A literature review

  1. Karol Polom MD, PhD1,†,*,
  2. Dawid Murawa MD, PhD1,
  3. Young-soo Rho2,
  4. Piotr Nowaczyk MD1,
  5. Michael Hünerbein MD, PhD3,
  6. Pawel Murawa MD, PhD1,2

Article first published online: 11 APR 2011

DOI: 10.1002/cncr.26087

Issue

Cancer

Cancer

Volume 117, Issue 21, pages 4812–4822, 1 November 2011

Additional Information

How to Cite

Polom, K., Murawa, D., Rho, Y.-s., Nowaczyk, P., Hünerbein, M. and Murawa, P. (2011), Current trends and emerging future of indocyanine green usage in surgery and oncology. Cancer, 117: 4812–4822. doi: 10.1002/cncr.26087

Author Information

  1. 1

    First Surgical Oncology and General Surgery Department, Wielkopolska Cancer Center, Poznan, Poland

  2. 2

    Department of Oncological Pathomorphology, Poznan University of Medical Sciences, Poznan, Poland

  3. 3

    Department of General Surgery and Surgical Oncology, Robert Rössle Hospital, Helios Hospital Berlin-Buch, Campus Charite Buch-Charité-Universitätsmedizin Berlin, Berlin, Germany

  1. †

    Fax: (011) 48618850601

*15 Garbary St., Poznan, Poland 61-866

Publication History

  1. Issue published online: 19 OCT 2011
  2. Article first published online: 11 APR 2011
  3. Manuscript Accepted: 10 FEB 2011
  4. Manuscript Revised: 8 JAN 2011
  5. Manuscript Received: 16 NOV 2010

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Keywords:

  • sentinel lymph node;
  • indocyanine green;
  • lymphedema;
  • free flaps;
  • axillary reverse mapping;
  • sentinel lymph node biopsy

Indocyanine green (ICG) fluorophore has had a significant impact in various fields of surgical oncology. In this review, the authors discuss its promising potential, in addition to assessing several challenges and limitations in the context of specific surgical procedures and ICG as a whole.

Abstract

Ever since Kitai first performed fluorescent navigation of sentinel lymph nodes (SLNs) using indocyanine green (ICG) dye with a charge-couple device and light emitting diodes, the intraoperative use of near infrared fluorescence has served a critical role in increasing our understanding in various fields of surgical oncology. Here the authors review the emerging role of the ICG fluorophore in the development of our comprehension of the lymphatic system and its use in SLN mapping and biopsy in various cancers. In addition, they introduce the novel role of ICG-guided video angiography as a new intraoperative method of assessing microvascular circulation. The authors attempt to discuss the promising potential in addition to assessing several challenges and limitations in the context of specific surgical procedures and ICG as a whole. PubMed and Medline literature databases were searched for ICG use in clinical surgical settings. Despite ICG's significant impact in various fields of surgical oncology, ICG is still in its nascent stages, and more in-depth studies need to be carried out to fully evaluate its potential and limitations. Cancer 2011;. © 2011 American Cancer Society.

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