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Risk factors for radiation-induced hypothyroidism
A literature-based meta-analysis
Version of Record online: 12 MAY 2011
Copyright © 2011 American Cancer Society
Volume 117, Issue 23, pages 5250–5260, 1 December 2011
How to Cite
Vogelius, I. R., Bentzen, S. M., Maraldo, M. V., Petersen, P. M. and Specht, L. (2011), Risk factors for radiation-induced hypothyroidism. Cancer, 117: 5250–5260. doi: 10.1002/cncr.26186
- Issue online: 18 NOV 2011
- Version of Record online: 12 MAY 2011
- Manuscript Revised: 22 MAR 2011
- Manuscript Accepted: 22 MAR 2011
- Manuscript Received: 8 FEB 2011
- The Lundbeck Foundation Center for Interventional Research in Radiation Oncology (CIRRO)
- The Danish Council for Strategic Research
- The Novo Nordisk Foundation
- National Cancer Institute. Grant Number: 2P30 CA 014520-34
- radiation oncology;
- radiation tolerance;
- thyroid-stimulating hormone;
A systematic overview and meta-analysis of studies reporting data on hypothyroidism (HT) after radiation therapy was conducted to identify risk factors for development of HT.
Published studies were identified from the PubMed and Embase databases and by hand-searching published reviews. Studies allowing the extraction of odds ratios (OR) for HT in 1 or more of several candidate clinical risk groups were included. A meta-analysis of the OR for development of HT with or without each of the candidate risk factors was performed. Furthermore, studies allowing the extraction of radiation dose-response data were identified for a meta-analysis of the dose-response curve.
Female gender (OR = 1.6; 95% confidence interval [CI], 1.3-1.9; P < .00001), surgery involving the thyroid gland (OR = 8.3; 95% CI, 5.7-12.0; P < .00001), or other neck surgery (OR = 1.7; 95% CI, 1.16-2.42; P = .006) were associated with a higher risk of HT. Caucasians were at higher risk of HT than African Americans (OR = 4.8; 95% CI, 2.8-8.5; P < .00001). The data showed association between lymphangiography and HT but with evidence of publication bias. There was a radiation dose-response relation with a 50% risk of HT at a dose of 45 Gy but with considerable variation in the dose response between studies. Chemotherapy and age were not associated with risk of HT in this analysis.
Several clinical risk factors for HT were identified. The risk of HT increases with increasing radiation dose, but the specific radiation dose response varies between the studies. The most likely cause of this heterogeneity is differences in follow-up between studies. Cancer 2011;. © 2011 American Cancer Society.