Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk

Authors

  • Li-Chung Chuang PhD,

    1. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    2. Genomics Research Center, Academia Sinica, Taipei, Taiwan
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  • Chung-Yi Hu PhD,

    1. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan
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  • Hui-Chi Chen PhD,

    1. Genomics Research Center, Academia Sinica, Taipei, Taiwan
    2. Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
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  • Pei-Jung Lin MS,

    1. Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan
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  • Borheng Lee MS,

    1. Yuan-Shan Research Institute, King Car Food Industrial Co. Ltd., I-Lan, Taiwan
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  • Ching-Yu Lin PhD,

    1. Schools of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan
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  • Mei-Hung Pan MS,

    1. Genomics Research Center, Academia Sinica, Taipei, Taiwan
    2. Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
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  • San-Lin You PhD,

    1. Genomics Research Center, Academia Sinica, Taipei, Taiwan
    2. Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
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  • Chang-Yao Hsieh MD,

    1. Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
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  • Chien-Jen Chen ScD,

    Corresponding author
    1. Genomics Research Center, Academia Sinica, Taipei, Taiwan
    2. Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
    • Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan

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    • Fax: (011) 886-2-2789-8784

  • Community-Based Cancer Screening Program-Human Papillomavirus Study Group

    1. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
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Abstract

BACKGROUND:

Only a small proportion of women infected with human papillomavirus type 18 (HPV18) may progress to persistent infection and cervical neoplasia. This community-based cohort study aimed to assess associations with human leukocyte antigen (HLA) class II genotypes for natural infection of HPV18 and subsequent risk of cervical neoplasia.

METHODS:

Among 10,190 cytologically normal participants, 125 with HPV18 infection were identified by HPV blot kit. HPV18 viral load at study entry was examined by real-time polymerase chain reaction; persistent infection was defined as HPV18 infection at 2 consecutive examinations.

RESULTS:

There was a significant association between HLA-DRB1*0403 allele and high HPV18 viral load (>1000 copies in 50 ng of total DNA) at study entry (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.0-25.2). After adjustment for age and viral load at study entry, haplotype HLA-DRB1*0405-DQA1*0301-DQB1*0302 was significantly associated with persistent HPV18 infection (OR, 13.3; 95% CI, 1.7-105.9). HLA-DRB1*0403 allele was also associated with a significantly increased risk of high-grade squamous intraepithelial lesion or cancer, showing a multivariate-adjusted hazard ratio (95% CI) of 18.1 (2.6-128.5).

CONCLUSIONS:

HLA-DRB1*0403 allele and HLA-DRB1*0405-DQA1*0301-DQB1*0302 haplotype may play important roles in determination of high viral load and persistent infection of HPV18 and subsequent cervical neoplasia risk. Cancer 2012;. © 2011 American Cancer Society.

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