Antonino Carbone is Chairman of the Department of Pathology at Oncology Referral Center-Aviano, is Coordinator of the National Telepathology Network (TESEO), and is a member of the Alliance Against Cancer.
Does “in situ lymphoma” occur as a distinct step in the development of nodular lymphocyte-predominant Hodgkin lymphoma?
Article first published online: 5 JUL 2011
Copyright © 2011 American Cancer Society
Volume 118, Issue 1, pages 15–16, 1 January 2012
How to Cite
Carbone, A. (2012), Does “in situ lymphoma” occur as a distinct step in the development of nodular lymphocyte-predominant Hodgkin lymphoma?. Cancer, 118: 15–16. doi: 10.1002/cncr.26228
- Issue published online: 16 DEC 2011
- Article first published online: 5 JUL 2011
- Manuscript Accepted: 8 APR 2011
- Manuscript Revised: 6 APR 2011
- Manuscript Received: 23 FEB 2011
- in situ lymphoma;
- nodular lymphocyte-predominant Hodgkin lymphoma;
- in situ Hodgkin lymphoma;
- nodular lymphocyte-predominant Hodgkin lymphoma variant;
- nodular lymphocyte-predominant Hodgkin lymphoma with small germinal centers
The concept of in situ neoplasia, already well acknowledged in epithelial tumors, has now been extended to lymphoid neoplasms. Among germinal center (GC)-derived lymphomas, a type of “in situ follicular lymphoma (FL)” has been described in which cells that strongly express BCL2 are observed in histologically abnormal follicles. In this commentary, the author suggests that another GC-derived lymphoma, ie, nodular lymphocyte-predominant Hodgkin lymphoma with a micronodular pattern in which small GCs or broken-up GCs are present within nodules, may be regarded as an early lesion limited to GC. Like “in situ FL,” this is likely to be an in situ step that potentially leads to overt lymphoma. Cancer 2012;. © 2011 American Cancer Society.