Trends in radical prostatectomy: centralization, robotics, and access to urologic cancer care

Authors

  • Karyn B. Stitzenberg MD, MPH,

    Corresponding author
    1. University of North Carolina, Chapel Hill, North Carolina
    2. American College of Surgeons Health Policy Research Institute, Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina
    • University of North Carolina, Division of Surgical Oncology, Department of Surgery, 170 Manning Drive, 1150 POB, CB# 7213, Chapel Hill, NC 27599-7213

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    • Fax: (919) 966-8806

  • Yu-Ning Wong MD, MSCE,

    1. Fox Chase Cancer Center, Philadelphia, Pennsylvania
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  • Matthew E. Nielsen MD,

    1. University of North Carolina, Chapel Hill, North Carolina
    2. American College of Surgeons Health Policy Research Institute, Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina
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  • Brian L. Egleston MPP, PhD,

    1. Fox Chase Cancer Center, Philadelphia, Pennsylvania
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  • Robert G. Uzzo MD

    1. Fox Chase Cancer Center, Philadelphia, Pennsylvania
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  • See editorial on pages 4-7, this issue.

Abstract

BACKGROUND:

Robotic surgery has been widely adopted for radical prostatectomy. We hypothesized that this change is rapidly shifting procedures away from hospitals that do not offer robotics and consequently increasing patient travel.

METHODS:

A population-based observational study of all prostatectomies for cancer in New York, New Jersey, and Pennsylvania from 2000 to 2009 was performed using hospital discharge data. Hospital procedure volume was defined as the number of prostatectomies performed for cancer in a given year. Straight-line travel distance to the treating hospital was calculated for each case. Hospitals were contacted to determine the year of acquisition of the first robot.

RESULTS:

From 2000 to 2009, the total number of prostatectomies performed annually increased substantially. The increase occurred almost entirely at the very high-volume centers (≥106 prostatectomies/year). The number of hospitals performing prostatectomy fell 37% from 2000 to 2009. By 2009, the 9% (21/244) of hospitals that had very high volume performed 57% of all prostatectomies, and the 35% (86/244) of hospitals with a robot performed 85% of all prostatectomies. The median travel distance increased 54% from 2000 to 2009 (P<.001). The proportion of patients traveling ≥15 miles increased from 24% to 40% (P < .001).

CONCLUSIONS:

Over the past decade, the number of radical prostatectomies performed has risen substantially. These procedures have been increasingly centralized at high-volume centers, leading to longer patient travel distances. Few prostatectomies are now performed at hospitals that do not offer robotic surgery. Cancer 2012;. © 2011 American Cancer Society.

Introduction

In 2000, the US Food and Drug Administration first approved a robotic surgery system for use for laparoscopic abdominal and pelvic procedures. Since then, robotic surgery has become increasingly widely adopted. According to the exclusive manufacturer, >1000 robots have been distributed in the United States.1 The first descriptions of robotic-assisted laparoscopic prostatectomy (RALP) were published in 2001.2-4 Subsequent studies have detailed the safety and potential advantages of RALP, and preliminary data suggest that RALP has rapidly become the most common approach to prostatectomy.5-11

There has been a simultaneous trend toward centralization of complex cancer procedures at high-volume centers.12 In response to studies documenting an association between hospital procedure volume and clinical outcomes, many have advocated centralization of procedures, such as prostatectomy, at high-volume centers.13-24 Recent studies document that practice patterns for some oncologic procedures are changing in response to these findings.12 This is particularly true for relatively uncommon cancers that require complex extirpative procedures, such as esophageal and pancreatic cancer. As these procedures have become centralized, the distances that patients travel for surgery have increased substantially.25 The degree to which centralization has occurred for prostate cancer is unknown. Although prostatectomy is a complex procedure, prostate cancer is far more common than esophageal or pancreatic cancer, so the extent and impact of centralization may be different.

This study evaluated how practice patterns have changed in the face of simultaneous trends toward increasing use of RALP and increasing centralization of cancer surgery. We hypothesized that over the past decade, prostatectomies have been centralized at higher-volume centers that offer robotic surgery, resulting in a relevant increase in travel distance for patients seeking prostate cancer care.

MATERIALS AND METHODS

A secondary data analysis was performed using inpatient discharge data from New Jersey, New York, and Pennsylvania. Each state mandates reporting of claims from all nonfederal hospitals. Databay Resources (Warrendale, PA) acquires the deidentified data from individual state agencies (State of New Jersey Department of Health and Senior Services, State of New York Statewide Planning and Research Cooperative System, Pennsylvania Healthcare Cost Containment Council) and produces a database suitable for secondary analysis. Available variables include demographic information, diagnosis codes (International Classification of Diseases, 9th Revision [ICD-9]), procedure codes (ICD-9), length of stay, disposition at discharge, and hospital charges. The study was exempted from full review and approved by the institutional review boards of the University of North Carolina and Fox Chase Cancer Center.

Men ≥18 years of age undergoing radical prostatectomy in the study area from 2000 to 2009 were included. Patients residing in the study area who underwent surgery outside of the study area were not captured; however, patients residing outside the study area who had surgery in the study area (inward border crossers) were included. All admissions with an ICD-9 procedure code for radical prostatectomy (60.5) and a diagnosis code for prostate cancer (185) were captured. Because there are no ICD-9 procedure codes specific for RALP or laparoscopic prostatectomy, these procedures could not be differentiated from open prostatectomy.

Patients were geocoded to a ZIP code centroid, which was available for every case, using a publicly available geocoding tool (Excel geocoding tool version 2; Juice Analytics, Herndon, VA, referencing Yahoo! Maps Web Services Geocoding API [Yahoo, Sunnyvale, CA]). Hospitals were geocoded to street address. Great-circle distance, a proven proxy for travel time, was calculated between cases and the hospitals where the procedures were performed [d = acos(sin(lat1).sin(lat2) + cos(lat1). cos(lat2).cos(long2 − long1)).R].26-28 Inward border crossers were excluded from the distance analyses. The mean travel distance for this group (≈4% of total population) was >500 miles, and inclusion of this small, distinct group would have disproportionately influenced the results.

Hospital procedure volume was calculated for each year individually. Because standard volume cutpoints do not exist for prostatectomy, previously defined methodology for defining hospital volume categories was used.25, 29 Five equal-sized groups of patients treated in 2000 were created based on procedure volume of the treating hospital. These quintiles were designated as very low, low, medium, high, and very high volume. These baseline 2000 volume cutpoints were then applied to each subsequent year to determine changes in the distribution of patients among volume categories over time.

Hospitals in the study area that owned a robot in 2009 were identified through communication with the exclusive vendor (Intuitive Surgical, Inc., Sunnyvale, CA). To add depth to the analysis, each hospital was contacted directly to determine the year of acquisition of the first robot at the facility. This information was successfully obtained for every hospital identified by the vendor as owning a robot in 2009. Lowess smoothers, fit separately for hospitals that eventually obtained robots and those that did not, were used.30 For hospitals that eventually obtained robots, time was measured as years from robot acquisition. Negative values indicate years before acquisition, and positive values indicate years after acquisition. For hospitals that never obtained robots, time was set as time from 2005, the midpoint of the study period. Multiple linear regression of procedure volume was used for hypothesis testing of time trends. To account for the correlation of observations within hospitals over time, we estimated the models using generalized estimating equations assuming an autoregressive (order 1) working correlation structure.31 The model included covariates for years from baseline, whether the hospital ever acquired a robot, whether the hospital had a robot in a given year, and interactions between the robot variables and years from baseline. STATA version 10 (StataCorp, College Station, TX) was used to create Figure 2 and for all statistical analyses. For Figure 4, all hospitals with robots in 2010 as reported by the vendor were geocoded to a ZIP code centroid and mapped.32

RESULTS

A total of 108,112 prostatectomies met inclusion criteria. The total number of prostatectomies performed annually increased substantially from 8,115 in 2000 to 10,241 in 2009 (Figure 1A). There was no significant change in the age or racial distribution of patients undergoing prostatectomy over time. All of the increase in prostatectomy volume occurred at high-volume centers. The odds of surgery at a very high-volume center increased more than 6-fold (odds ratio, 6.04; 95% confidence interval [CI], 5.74-6.37) over the study period. Both the total number and proportion of cases performed at hospitals in lower-volume categories declined over time. At any given time, there were 590-600 nonfederal acute care hospitals operating in the study area. Of these, 462 performed ≥1 eligible cases during the study period, but the annual number of hospitals performing prostatectomies steadily decreased from 390 in 2000 to 244 in 2009 (37% decrease) (Figure 1B). In 2000, the majority (242/390; 62%) of hospitals performing prostatectomies were very low-volume (1-15/y) and accounted for only 19% (1,567/8,115) of prostatectomies in the study area. Meanwhile, only 8 of the 390 hospitals (2%) met criteria as very high-volume centers (≥106/y), accounting for 20% (1,631/8,115) of procedures. By 2009, the majority (145/244; 59%) of hospitals performing prostatectomy remained very low-volume (1-15/y) but accounted for only 8% (845/10,241) of all procedures The number of very high-volume centers (≥106/y) had grown to 21/244 (9%), and these centers now performed the majority (5,828/10,241; 57%) of prostatectomies in the study area.

Figure 1.

(A) Graph shows the total number of prostatectomies performed annually in New Jersey, New York, and Pennsylvania, 2000-2009. (B) Graph shows the total number of hospitals performing prostatectomy each year in New Jersey, New York, and Pennsylvania, 2000-2009. During this time period, there were roughly 590-600 acute care hospitals in the study area.

Only 1 of the 462 hospitals that performed a prostatectomy during the study period had a robot at the start of 2000, but by 2009, 18.6% of these hospitals had acquired a robot. In 2009, 11.0% of very low-volume centers (1-15/y), 37.0% of low-volume centers (16-29/y), 59.1% of medium-volume centers (30-53/y), 89.7% of high-volume centers (54-105/y), and 100.0% of very high-volume centers (≥106/y) owned a robot. In total, 35.3% (86/244) of the hospitals performing prostatectomy had a robot in 2009, and these centers performed 84.6% (8,662/10,241) of prostatectomies in the study area.

The mean prostatectomy volume for hospitals that never obtained a robot was 10.2/y (SD 14.9) in 2000. For these hospitals, the mean volume decreased by 0.7/y annually over the study period (95% CI, −0.8 to −0.5) (Figure 2). In contrast, the mean procedure volume for hospitals that eventually obtained a robot was 48.4/y (SD 59.8) in 2000. Prior to robot acquisition, there was a trend toward gradually increasing procedure volume at hospitals that eventually acquired a robot (mean 1.3/y annual increase; 95% CI, −0.8 to 3.4). During the year of robot acquisition, there was a ramping-up phase with average hospital volume increasing by 8.5/y (95% CI, 3.9-13.0) above historical trends. After robot acquisition, volume increased even more rapidly (mean 12.4/y increase; 95% CI, 5.4-19.4) continuing annually.

Figure 2.

The relationship between hospital prostatectomy volume and robot acquisition is shown. Each dot represents a single hospital in a single year. Hospitals that acquired a robot during the study period are shown in red; those that never obtained a robot are shown in blue. For the hospitals that acquired a robot, year 0 is the year the robot was acquired. For the hospitals that never acquired a robot, year 2005 (midway through the study period) was designated as year 0. The fitted curves show the trends in prostatectomy volume.

Median travel distance was proportional to hospital prostatectomy volume (Figure 3). This relationship persisted throughout the study period. As a result, the median travel distance for prostatectomy increased 54% from 6.9 miles in 2000 to 10.6 miles in 2009. The proportion of patients traveling ≥15 miles increased from 24% in 2000 to 40% in 2009 (P < .001).

Figure 3.

Graph shows the median distance traveled in miles from the patient's home to the hospital where the prostatectomy was performed.

DISCUSSION

Two major forces have altered patterns of care for prostate cancer surgery over the past decade. Because high surgical volumes have been associated with improved cancer control and lower rates of morbidity and mortality following radical prostatectomy, many have advocated centralization of prostatectomies at higher-volume centers.15-22, 24, 29 During the same time period, there has been rapid diffusion of RALP. First described about a decade ago, RALP has quickly emerged as the most common technique for radical prostatectomy.33 Between 2003 and 2006-2007, the use of RALP increased almost 5-fold in the Medicare population (9.2% vs 43% of all prostatectomies).34 This study highlights how these changes are impacting prostate cancer care on the patient, hospital, and population level.

The number of radical prostatectomies performed annually has increased over the past decade and in particular over the past 5 years. Meanwhile, prostatectomies have been progressively centralized at high-volume centers. Unlike other cancers for which centralization of extirpative procedures has occurred steadily over time, there was little centralization of prostatectomy evident until the publication of the first major studies advocating RALP.25, 35-37 Beginning in 2004-2005, a rapid shift to higher-volume centers ensued. Within 3 years, few prostatectomies were performed at centers without robotic surgery capabilities. The overall result has been a sudden, population-wide, technology-driven centralization of procedures that is without precedent.

The interplay of these trends is supported by the fact that acquisition of a robot led to a rapid increase in the number of prostatectomies performed at a given hospital and that hospitals that did not acquire a robot performed fewer prostatectomies over time. Nevertheless, a few hospitals remain in the low-volume categories for prostatectomy despite robot acquisition, suggesting that volume is a dynamic influenced by the complex interplay between hospitals and professional staff, where uptake of robotic techniques requires both hospital investment in technology and the presence of surgeons able to perform the procedures.

On a population level, rapid centralization has been an unintended but potentially beneficial consequence of the introduction of robotics. Regardless, the full impact of the introduction and uptake of RALP on the triad of quality, cost, and access needs to be explored. Since publication of initial studies, RALP has been heavily marketed to patients, surgeons, and hospitals as an attractive alternative to traditional open prostatectomy with the promise of shorter hospitalization, faster recovery, and minimal blood loss. However, observational studies have also suggested that patients may have higher rates of complications, such as incontinence and erectile dysfunction, following minimally invasive prostatectomies.34, 38 One study found that patients undergoing RALP had greater dissatisfaction and regret with their treatment decision compared with patients who underwent open prostatectomy, likely due to heightened expectations and subsequent disappointment with this “innovative” technology.39 In addition, there is a steep learning curve for surgeons who had been trained to perform traditional open procedures.40-41 The impact of the early end of this learning curve on population-level cancer control and functional outcomes is not known. It is possible that the improvements in quality resultant from centralization could be offset, at least in part, by the higher complication rate associated with RALP, particularly early in the learning curve. The reported experience of surgeons at large referral centers supports the theory that outcomes improve with increased surgical experience.15, 40-43 Ultimately, however, no studies to date demonstrate that RALP, even in experienced hands, leads to improved overall cancer control or functional outcomes compared with open prostatectomy.

The economic impact of the rapid diffusion of RALP also deserves consideration. The high up-front capital investment associated with robot acquisition ($1.2-1.7 million), annual maintenance contracts ($150,000/robot), and disposable instruments results in much greater direct costs compared with open prostatectomy.44-46 Given diagnosis-based reimbursement in the United States, most hospitals receive little or no additional payment to offset these added costs. Many hospitals have marketed robotic surgery heavily to patients, likely in an effort to recoup the fixed capital investment costs of robot acquisition and maintenance, which may be amortized over a given volume of cases. This revenue shift places an additional burden on the health care system in exchange for potential yet incalculable societal benefits of more rapid convalescence and centralized care.

Many investigators have attempted to quantify the additional costs of this technology. In an early study, Lotan et al.46 optimistically assumed a utilization rate of 300 cases/y (far in excess of our upper quintile) and estimated the cost of RALP to be ≈$2500 more per case than open prostatectomy ($857/case for the robot + $1705/case for disposable instruments). Another analysis found that the “break even” point for RALP versus open prostatectomy was between 10 and 15 cases/wk, again well above hospital volumes in this study, where only 2.9% of hospitals (7/244) performed >300 prostatectomies in 2009.45 Another group of investigators estimated an increase of $2315 in median direct costs for RALP compared with open prostatectomy due to additional surgical supply and operating room costs. After adding the fixed costs of the robot, the total additional cost burden of RALP increased to $4713/case, assuming an average of 126 cases/year.46 There is additional cost associated with the learning curve; however, this is difficult to quantify, because the number of RALP each surgeon must complete to be competent varies widely.41 Based on 8 published series, 1 group estimated the average learning curve was 77 cases, resulting in $217,034 in additional operating room and anesthesia costs.47 Given that published studies have not demonstrated superior oncologic and functional outcomes for RALP over an open approach, many hospitals, insurers, and federal agencies question both the comparative effectiveness and the cost effectiveness of this new technology.38, 46, 48 Understanding the extent to which individual and societal benefits may offset the indisputable direct cost disadvantages of RALP requires additional study. With >1000 robotic surgical systems installed in the past decade in the United States, the scale of these economic considerations is considerable.

The impact of RALP and centralization on geographic access to care for prostate cancer has not been examined previously. In this study, the distance patients traveled to reach the treating hospital increased >50% over the study period. This is consistent with previous work demonstrating that informal centralization results in increased patient travel.25 With market-driven centralization in the United States, universal patient access is only a minor determinant of the geographic location of high-volume centers. Consequently, the geographic distribution of high-volume centers and robots is not necessarily optimized for patient travel and access to care (Figure 4). Although the absolute increase in median straight-line travel distance was only 3.7 miles, it is important to remember that straight-line distance underestimates actual road mileage by 20%-40%.25, 28, 49 This increase in travel is particularly remarkable considering the study area is a densely populated region with extensive health care resources and relatively few rural counties. As a result, findings from this region likely underestimate the impact of centralization on patient travel burden nationwide.

Figure 4.

(A) Geographic location, by ZIP code, of United States hospitals with robots in 2010 is shown. Not shown: There are 2 hospitals with robots in Alaska, both in the same ZIP code in Anchorage, Alaska, and there are 2 hospitals with robots in Hawaii, both in Honolulu but in different ZIP codes. (B) Geographic location, by ZIP code of hospitals with robots in New Jersey, New York, and Pennsylvania in 2010 is shown.

In previous studies, we have demonstrated that patterns of centralization occurring in this region are similar to those seen nationwide.12, 25 Similarly, the uptake of robotics is not unique to this region, but is occurring nationally (Figure 4). Nevertheless, trends in this region may not completely represent practice patterns across the country. For example, <10% of our study population lived in rural counties, so this study may underestimate the impact of centralization on travel distance and overestimate the availability of prostate cancer care for patients from more rural areas of the country.

Another major limitation of hospital discharge data is the lack of detailed case information. For example, although we examined the influence of robot acquisition, we do not know the proportion of prostatectomies at a hospital with a robot that are actually performed robotically. Additional information about the hospitals (ie, teaching status, ownership) and the patients (ie, comorbidity, cancer staging) would have enhanced our analysis but was not available. In particular, without information on tumor stage, Gleason score, prostate-specific antigen levels, and other factors used to risk-stratify cancer patients, we were unable to determine whether the disease severity of patients treated with prostatectomy changed over time.

Similarly, we were unable to examine how centralization, the introduction of robotics, and travel influenced the relative frequency with which surgery, active surveillance, and radiation therapy were used to treat localized disease. Prostate cancer differs from other cancers to the extent that surgical therapy is not the clear gold standard, but rather one of several equivalently appropriate treatment options. The vast majority of men diagnosed with prostate cancer in the United States during the study period had clinically localized disease.50 For these men, surgery, radiation therapy, and in some cases active surveillance are all considered acceptable treatment options.51 The perception that RALP was associated with quicker recovery or fewer adverse effects may have led patients with indolent disease, who previously would have chosen active surveillance, to proceed with surgery. These behavioral economics issues are important and deserve attention in future studies.

Conclusion

Over the past decade, there has been widespread adoption of RALP and increasing centralization of prostate cancer surgery at high-volume centers. These changes have had a major impact on patterns of care for prostate cancer. On a population level, the number of radical prostatectomies performed has risen substantially, but the true impact on patient level outcomes is unknown. Future studies should focus on the impact of these trends on access to care and cost, in addition to cancer control and functional outcomes.

FUNDING SOURCES

Karen B. Stitzenberg is supported in part by the University Cancer Research Fund. Matthew E. Nielsen is supported in part by NIH/NCRR 1KL2RR025746 and the University Cancer Research Fund. Brian L. Egleston, Robert G. Uzzo, and Yu-Ning Wong are supported in part by NIH P30 CA06927.

Acknowledgements

We acknowledge the work of Stephen Gazda and Olivia Hamilton in data collection and preparation.

CONFLICT OF INTEREST DISCLOSURES

The authors made no disclosures.

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