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Better prognosis for patients with del(7q) than for patients with monosomy 7 in myelodysplastic syndrome†
Article first published online: 29 JUN 2011
Copyright © 2011 American Cancer Society
Volume 118, Issue 1, pages 127–133, 1 January 2012
How to Cite
Cordoba, I., González-Porras, J. R., Nomdedeu, B., Luño, E., de Paz, R., Such, E., Tormo, M., Vallespi, T., Collado, R., Xicoy, B., Andreu, R., Muñoz, J. A., Solé, F., Cervera, J., del Cañizo, C. and On behalf of the Spanish Myelodysplastic Syndrome Registry (2012), Better prognosis for patients with del(7q) than for patients with monosomy 7 in myelodysplastic syndrome. Cancer, 118: 127–133. doi: 10.1002/cncr.26279
We thank V. Marco, S. Bonanad, L. Benlloch, D. Costa, J. Bueno, T. Bernal, and all members of the Spanish MDS Registry along with Phil Mason for their excellent technical assistance.
- Issue published online: 16 DEC 2011
- Article first published online: 29 JUN 2011
- Manuscript Revised: 21 APR 2011
- Manuscript Accepted: 21 APR 2011
- Manuscript Received: 15 MAR 2011
- myelodysplastic syndrome;
- monosomy 7;
Abnormalities involving chromosome 7 are frequent in myelodysplastic syndrome (MDS) and suggest a poor prognosis.
The authors examined the hypothesis that the clinical features and survival associated with isolated deletion (del) of part of the long arm of chromosome 7 (7q) in MDS are different from those associated with isolated monosomy 7 (complete loss of chromosome 7). In total, 133 patients with a diagnosis of de novo MDS (according to the World Health Organization [WHO] classification) and chromosome 7 abnormalities in the Spanish MDS Registry were evaluated retrospectively. Four karyotypic groups were identified: isolated del(7q) (n = 29), isolated monosomy 7 (n = 27), del(7q) with additional abnormalities (n = 24), and monosomy 7 with additional abnormalities (n = 53).
Isolated del(7q) was more frequent in patients with less advanced MDS according to the WHO classification or the International Prognostic Scoring System. In addition, isolated del(7q) was associated with fewer blasts in bone marrow than other cytogenetics groups. Survival was significantly superior in patients with isolated del(7) than in those with isolated monosomy 7, del(7q) with additional abnormalities, or monosomy 7 with additional abnormalities. On multivariate analysis, age, the percentage of blasts in bone marrow, and other chromosome 7 abnormalities apart from isolated del(7q) were identified as independent risk factors for survival.
The current results demonstrated that patients who had MDS with isolated del(7q) had some distinct clinical-pathologic characteristics as well as better survival than patients who had MDS with isolated monosomy 7. Cancer 2012;. © 2011 American Cancer Society.