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Keywords:

  • non-small cell lung cancer;
  • radiotherapy;
  • estrogen receptor-α;
  • progesterone receptor;
  • androgen receptor

Abstract

BACKGROUND:

The current study was performed to investigate the potential impact of tumor cell expression of estrogen receptor-α (ER-α), progesterone receptor (PR), and androgen receptor (AR) on the outcomes of patients who received radiotherapy (RT) for non-small cell lung cancer (NSCLC).

METHODS:

Tumor cell expression of ER-α, PR, and AR as well as 9 additional potential prognostic factors were retrospectively evaluated in 64 patients who underwent RT for AJCC stage II/III NSCLC. The endpoints investigated were locoregional control, metastases-free survival, and overall survival. The additional potential prognostic factors were age, gender, Karnofsky performance score, histology, T classification, N classification, surgery, smoking during RT, and hemoglobin levels during RT. Subgroup analyses were performed for women and men.

RESULTS:

On univariate analysis, locoregional control was not found to be associated with expression of PR or AR. ER-α expression demonstrated a strong trend toward worse locoregional control. On multivariate analysis, ER-α expression was found to be significantly associated with worse locoregional control (risk ratio [RR], 3.12; P = .035). On univariate analysis, metastases-free survival was not associated with expression of ER-α, PR, or AR. On univariate analysis, survival was found to be negatively associated with expression of ER-α (P = .003) but not with PR or AR expression. On multivariate analysis, ER-α expression maintained significance (RR, 2.73; P = .022).

CONCLUSIONS:

Tumor cell expression of ER-α was found to be a negative prognostic factor for treatment outcomes in both women and men. Expression of PR and AR was not associated with outcomes. Cancer 2012;. © 2011 American Cancer Society.