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The prognostic impact of tumor cell expression of estrogen receptor-α, progesterone receptor, and androgen receptor in patients irradiated for nonsmall cell lung cancer†
Article first published online: 28 JUN 2011
Copyright © 2011 American Cancer Society
Volume 118, Issue 1, pages 157–163, 1 January 2012
How to Cite
Rades, D., Setter, C., Dahl, O., Schild, S. E. and Noack, F. (2012), The prognostic impact of tumor cell expression of estrogen receptor-α, progesterone receptor, and androgen receptor in patients irradiated for nonsmall cell lung cancer. Cancer, 118: 157–163. doi: 10.1002/cncr.26282
We thank Ms. Ilona Schliephake and Ms. Christine Drengenes for their excellent technical assistance.
- Issue published online: 16 DEC 2011
- Article first published online: 28 JUN 2011
- Manuscript Accepted: 22 APR 2011
- Manuscript Revised: 10 APR 2011
- Manuscript Received: 8 MAR 2011
- non-small cell lung cancer;
- estrogen receptor-α;
- progesterone receptor;
- androgen receptor
The current study was performed to investigate the potential impact of tumor cell expression of estrogen receptor-α (ER-α), progesterone receptor (PR), and androgen receptor (AR) on the outcomes of patients who received radiotherapy (RT) for non-small cell lung cancer (NSCLC).
Tumor cell expression of ER-α, PR, and AR as well as 9 additional potential prognostic factors were retrospectively evaluated in 64 patients who underwent RT for AJCC stage II/III NSCLC. The endpoints investigated were locoregional control, metastases-free survival, and overall survival. The additional potential prognostic factors were age, gender, Karnofsky performance score, histology, T classification, N classification, surgery, smoking during RT, and hemoglobin levels during RT. Subgroup analyses were performed for women and men.
On univariate analysis, locoregional control was not found to be associated with expression of PR or AR. ER-α expression demonstrated a strong trend toward worse locoregional control. On multivariate analysis, ER-α expression was found to be significantly associated with worse locoregional control (risk ratio [RR], 3.12; P = .035). On univariate analysis, metastases-free survival was not associated with expression of ER-α, PR, or AR. On univariate analysis, survival was found to be negatively associated with expression of ER-α (P = .003) but not with PR or AR expression. On multivariate analysis, ER-α expression maintained significance (RR, 2.73; P = .022).
Tumor cell expression of ER-α was found to be a negative prognostic factor for treatment outcomes in both women and men. Expression of PR and AR was not associated with outcomes. Cancer 2012;. © 2011 American Cancer Society.