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Clinical behavior and treatment outcome of primary nasal diffuse large B-cell lymphoma†
Version of Record online: 11 AUG 2011
Copyright © 2011 American Cancer Society
Volume 118, Issue 6, pages 1593–1598, 15 March 2012
How to Cite
Lu, N.-N., Li, Y.-X., Wang, W.-H., Jin, J., Song, Y.-W., Zhou, L.-Q., Wang, S.-L., Liu, Y.-P., Liu, X.-F. and Yu, Z.-H. (2012), Clinical behavior and treatment outcome of primary nasal diffuse large B-cell lymphoma. Cancer, 118: 1593–1598. doi: 10.1002/cncr.26452
Y.-X.L. designed the research, analyzed the data, and wrote the article; N.-N.L. analyzed the data and wrote the article; W.-H.W., J.J., Y.-W.S., L.-Q.Z., S.-L.W., L.-Y.P., X.-F.L., and Z.-H.Y. selected the patients and analyzed the clinical data.
- Issue online: 2 MAR 2012
- Version of Record online: 11 AUG 2011
- Manuscript Accepted: 23 JUN 2011
- Manuscript Revised: 21 JUN 2011
- Manuscript Received: 4 MAY 2011
- B-cell lymphoma;
- nasal cavity;
- clinical feature
Nasal diffuse large B-cell lymphoma (DLBCL) is rare. The objective of this study was to evaluate the clinical features and treatment outcomes of patients with nasal DLBCL.
Twenty-five patients were included in the study. All patients received combination chemotherapy with or without radiotherapy.
Patients with nasal DLBCL usually were older and were predominantly men with early stage disease, low frequency of B symptoms and elevated lactate dehydrogenase (LDH), good performance status, and a low-risk international prognostic index (IPI) score. The overall response rate after initial treatment was 76%, the 3-year overall survival (OS) rate for the whole group was 44%, and the median OS was 35 months. Performance status and IPI were significant prognostic factors for OS. For patients with IPI scores of 0 or 1, the 3-year OS rate was 54%, and the median OS was 52 months compared with 17% and 11 months, respectively, for patients with IPI scores of 2 or 3 (P = .033). The prognosis for patients who achieved a complete response (CR) was significantly better than that for patients who did not achieve a CR. Extranodal spread was the primary pattern of failure.
The current results indicated that primary nasal DLBCL appears to have distinct clinical features; its poor outcome and propensity for extranodal failure illustrate the need for innovative therapies. Cancer 2011;. © 2011 American Cancer Society.