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Original Article
Prognostic impact of discordant results from cytogenetics and flow cytometry in patients with acute myeloid leukemia undergoing hematopoietic cell transplantation†‡
Article first published online: 16 SEP 2011
DOI: 10.1002/cncr.26539
Copyright © 2011 American Cancer Society
Additional Information
How to Cite
Fang, M., Storer, B., Wood, B., Gyurkocza, B., Sandmaier, B. M. and Appelbaum, F. R. (2012), Prognostic impact of discordant results from cytogenetics and flow cytometry in patients with acute myeloid leukemia undergoing hematopoietic cell transplantation. Cancer, 118: 2411–2419. doi: 10.1002/cncr.26539
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We thank Gary Schoch, a clinical research database manager from Fred Hutchinson Cancer Research Center, and Stacie Thomas (secretary) and Lisa Zhang (clinical technologist) from the Cytogenetics Laboratory of Seattle Cancer Care Alliance for their help with data collection.
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M.F. and F.R.A. conceptualized the project. M.F. and B.W. collected and reviewed all the data. B.G. and B.M.S. collected nonmyeloablative data. M.F. and B.S. analyzed the data. All authors contributed to writing and editing the article.
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Fax: (206) 288-7567
Publication History
- Issue published online: 20 APR 2012
- Article first published online: 16 SEP 2011
- Manuscript Accepted: 10 AUG 2011
- Manuscript Revised: 27 JUL 2011
- Manuscript Received: 1 JUN 2011
REFERENCES
- 1, , , et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood. 2000; 96: 4075-4083.
- 2, , , et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998; 92: 2322-2333.
- 3, , , et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010; 115: 453-474.
- 4, , , et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002; 100: 4325-4336.
- 5, , , et al. Abnormal cytogenetics at date of morphologic complete remission predicts short overall and disease-free survival, and higher relapse rate in adult acute myeloid leukemia: results from Cancer and Leukemia Group B Study 8461. J Clin Oncol. 2004; 22: 2410-2418.
- 6, , , et al. Cytogenetics for detection of minimal residual disease in acute myeloblastic leukemia. Leukemia. 1992; 6: 500-506.
- 7, , , et al. Comparison of cytogenetic and molecular cytogenetic detection of chromosome abnormalities in 240 consecutive adult patients with acute myeloid leukemia. J Clin Oncol. 2002; 20: 2480-2485.
- 8. Myeloid malignancies: myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Clin Lab Med. 2007; 27: 551-575.
- 9. Nine-color and 10-color flow cytometry in the clinical laboratory. Arch Pathol Lab Med. 2006; 130: 680-690.
- 10, , , et al. Early immunophenotypical evaluation of minimal residual disease in acute myeloid leukemia identifies different patient risk groups and may contribute to postinduction treatment stratification. Blood. 2001; 98: 1746-1751.
- 11, , , , , . Prognostic impact of early response to induction therapy as assessed by multiparameter flow cytometry in acute myeloid leukemia. Haematologica. 2004; 89: 528-540.
- 12, , , et al. Toward optimization of postremission therapy for residual disease-positive patients with acute myeloid leukemia. J Clin Oncol. 2008; 26: 4944-4951.
- 13. Molecular diagnosis and clinical decisions in adult acute leukemia. Semin Hematol. 1999; 36: 401-410.
- 14, , , et al. Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. Blood. 1996; 87: 4789-4796.
- 15, , , et al. Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood. 1995; 85: 2632-2638.
- 16Shaffer LG, Slovak ML, Campbell LJ, eds. An International System for Human Cytogenetic Nomenclature. Unionville, CT: S. Karger Publishers, Inc.; 2009.
- 17, . An International System for Human Cytogenetic Nomenclature. Unionville, CT: S. Karger Publishers, Inc, 2005.
- 18
- 19, , , et al. Impact of pretransplantation minimal residual disease, as detected by multiparametric flow cytometry, on outcome of myeloablative hematopoietic cell transplantation for acute myeloid leukemia. J Clin Oncol. 2011; 29: 1190-1197.
- 20, , , et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood. 1990; 75: 555-562.
- 21, , , , , . Evaluation of complete disease remission in acute myeloid leukemia: a prospective study based on cytomorphology, interphase fluorescence in situ hybridization, and immunophenotyping during follow-up in patients with acute myeloid leukemia. Cancer. 2006; 106: 839-847.

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