Patterns of care and treatment outcomes for elderly women with cervical cancer

Authors

  • Charu Sharma MD,

    1. Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, New York
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  • Israel Deutsch MD,

    1. Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, New York
    2. Herbert Irving Comprehensive Cancer Center, New York, New York
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  • David P. Horowitz MD,

    1. Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, New York
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  • Dawn L. Hershman MD,

    1. Herbert Irving Comprehensive Cancer Center, New York, New York
    2. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
    3. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York
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  • Sharyn N. Lewin MD,

    1. Herbert Irving Comprehensive Cancer Center, New York, New York
    2. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York
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  • Yu-Shiang Lu MS,

    1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York
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  • Alfred I. Neugut MD,

    1. Herbert Irving Comprehensive Cancer Center, New York, New York
    2. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
    3. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York
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  • Thomas J. Herzog MD,

    1. Herbert Irving Comprehensive Cancer Center, New York, New York
    2. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York
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  • Clifford K. Chao MD,

    1. Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, New York
    2. Herbert Irving Comprehensive Cancer Center, New York, New York
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  • Jason D. Wright MD

    Corresponding author
    1. Herbert Irving Comprehensive Cancer Center, New York, New York
    2. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York
    • Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, Eighth Floor, New York, NY 10032

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    • Fax: (212) 305-3412


Abstract

BACKGROUND:

Cervical cancer is common in the elderly. The authors examined the patterns of care, treatment, and outcomes of elderly women with cervical cancer.

METHODS:

Women with cervical cancer diagnosed between 1988 and 2005 and registered in the Surveillance, Epidemiology, and End Results database were analyzed. Patients were stratified by age: <50, 50 to 59, 60 to 69, 70 to 79, and ≥80 years. Multivariate logistic regression models were constructed to examine treatment; cancer-specific survival was examined using Cox proportional hazards models.

RESULTS:

A total of 28,902 women were identified, including 2543 women 70 to 79 years old and 1364 ≥80 years. For women with early stage (IB1-IIA) tumors, primary surgery was performed in 82.0% of women <50 years old compared with 54.5% of those 70 to 79 years old and 33.2% of those ≥80 years old (P < .0001). For women treated surgically, lymphadenectomy was performed in 66.8% of women <50 years old versus 9.1% of patients ≥80 years old (P < .0001). Compared with patients <50 years old, those >80 years old were less likely to undergo radical hysterectomy (odds ratio [OR], 0.10; 95% confidence interval [CI], 0.07-0.14) and lymphadenectomy (OR, 0.11; 95% CI, 0.08-0.16) and to receive adjuvant radiation therapy (OR, 0.06; 95% CI, 0.01-0.35). Among women with stage IIB-IVA disease, use of brachytherapy declined with age (P < .0001). For women with stage IB1-IIA tumors, the hazard ratio for death from cancer was 1.35 (95% CI, 1.16-1.58) for women 70 to 79 years old and 2.08 (95% CI, 1.72-2.48) for those ≥80 years old compared with younger women.

CONCLUSIONS:

Elderly women with cervical cancer are less likely to undergo surgery, receive adjuvant radiation, and receive brachytherapy. After adjusting for treatment disparities, cancer-specific mortality is higher in older women. Cancer 2012;3618–3626. © 2011 American Cancer Society.

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