Fax: (216) 983-0347
Prevalence and predictors of interval colorectal cancers in Medicare beneficiaries
Article first published online: 11 OCT 2011
Copyright © 2011 American Cancer Society
Volume 118, Issue 12, pages 3044–3052, 15 June 2012
How to Cite
Cooper, G. S., Xu, F., Barnholtz Sloan, J. S., Schluchter, M. D. and Koroukian, S. M. (2012), Prevalence and predictors of interval colorectal cancers in Medicare beneficiaries. Cancer, 118: 3044–3052. doi: 10.1002/cncr.26602
Fax: (216) 983-0347
- Issue published online: 4 JUN 2012
- Article first published online: 11 OCT 2011
- Manuscript Accepted: 18 AUG 2011
- Manuscript Revised: 16 AUG 2011
- Manuscript Received: 29 APR 2011
- colorectal cancer;
- cancer screening;
- Surveillance, Epidemiology, and End Results Program
After a colonoscopy that is negative for cancer, a subset of patients may be diagnosed with colorectal cancer, also termed interval cancer. The frequency and predictors have not been well studied in a population-based US cohort.
The authors used the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database to identify 57,839 patients aged ≥69 years who were diagnosed with colorectal cancer between 1994 and 2005 and who underwent colonoscopy within 6 months of cancer diagnosis. Colonoscopy performed between 6 and 36 months before cancer diagnosis was a proxy for interval cancer.
By using the case definition, 7.2% of patients developed interval cancers. Factors that were associated with interval cancers included proximal tumor location (distal colon: multivariable odds ratio [OR], 0.42; 95% confidence interval [CI], 0.390-0.46; rectum: OR, 0.47; 95% CI, 0.42-0.53), increased comorbidity (OR, 1.89; 95% CI, 1.68 2.14 for ≥3 comorbidities), a previous diagnosis of diverticulosis (OR, 6.00; 95% CI, 5.57-6.46), and prior polypectomy (OR, 1.74; 95% CI, 1.62-1.87). Risk factors at the endoscopist level included a lower polypectomy rate (OR, 0.70; 95% CI, 0.63-0.78 for the highest quartile), higher colonoscopy volume (OR, 1.27; 95% CI, 1.13-1.43), and specialty other than gastroenterology (colorectal surgery: OR, 1.45; 95% CI, 1.16-1.83; general surgery: OR, 1.42; 95% CI, 1.24-1.62; internal medicine: OR, 1.38; 95% CI, 1.17-1.63; family practice: OR, 1.16; 95% CI, 1.00-1.35).
A significant proportion of patients developed interval colorectal cancer, particularly in the proximal colon. Contributing factors likely included both procedural and biologic factors, emphasizing the importance of meticulous examination of the mucosa. Cancer 2012;118: 3044–52. © 2011 American Cancer Society.