Improving prognosis of glioblastoma in the 21st century: Who has benefited most?

Authors

  • Yaacov Richard Lawrence MRCP,

    Corresponding author
    1. Department of Radiation Oncology, Sheba Medical Center affiliated with Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel
    2. Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
    • Center for Translational Research, Department of Radiation Oncology, Sheba Medical Center, Ramat Gan, Israel, 52621

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    • Fax: (011) 972-3-530-8036

  • Mark V. Mishra MD,

    1. Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
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    • The first 2 authors contributed equally to this work.

  • Maria Werner-Wasik MD,

    1. Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
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  • David W. Andrews MD,

    1. Department of Neurosurgery, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
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  • Timothy N. Showalter MD,

    1. Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
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  • Jon Glass MD,

    1. Department of Neurosurgery, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
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  • Xinglei Shen MD,

    1. Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
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  • Zvi Symon MD,

    1. Department of Radiation Oncology, Sheba Medical Center affiliated with Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel
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  • Adam P. Dicker MD, PhD

    1. Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Bodine Cancer Center, Philadelphia, Pennsylvania
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Abstract

BACKGROUND:

Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults. Temozolomide was rapidly incorporated into first-line treatment following the publication of the pivotal European Organization for Research and Treatment of Cancer–National Cancer Institute of Canada phase 3 trial in 2005. However, in the trial, enrollment was limited to younger patients with good performance status. Therefore, this study performed a population-based survival analysis of patients with newly diagnosed GBM covering the period before and after the introduction of temozolomide.

METHODS:

Survival statistics and clinical and demographic variables were extracted from the Survival, Epidemiology and End Results Database for patients diagnosed with GBM from 2001 to 2007. Mean regional income for each patient was also collected. Survival was analyzed using the Kaplan-Meier method and proportional hazard models.

RESULTS:

A total of 13,003 adult patients diagnosed with a GBM were identified. Prognostic variables included age <70 years, use of radiation, gross total resection, and residence in a high-income district (P < .001). Between 2001 and 2007, the median survival time increased from 7 to 9 months for the entire population. The 1-year survival increased from 29% to 39%. Prognosis of patients aged 70 or more years did not improve over this time. Over the study period, the absolute disparity in 1-year survival between low- and high-income districts increased from 6.6% to 10.1%.

CONCLUSIONS:

There has been a stepwise improvement in the overall survival of patients with GBM between 2001 and 2007. This improvement has been confined to patients <70 years of age and has been most prominent among patients living in high-income districts. Cancer 2012. © 2011 American Cancer Society.

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