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Predicting survival of patients with hypocellular myelodysplastic syndrome†
Development of a disease-specific prognostic score system
Article first published online: 17 JAN 2012
Copyright © 2011 American Cancer Society
Volume 118, Issue 18, pages 4462–4470, 15 September 2012
How to Cite
Tong, W.-G., Quintás-Cardama, A., Kadia, T., Borthakur, G., Jabbour, E., Ravandi, F., Faderl, S., Wierda, W., Pierce, S., Shan, J., Bueso-Ramos, C., Kantarjian, H. and Garcia-Manero, G. (2012), Predicting survival of patients with hypocellular myelodysplastic syndrome. Cancer, 118: 4462–4470. doi: 10.1002/cncr.27420
W.-G.T. and A.Q.-C. wrote the paper and analyzed the data. T.K., G.B., E.J., F.R., S.F., W.W., and H.K. contributed patients, helped write the paper, and analyzed the data. S.P. and J.S. performed part of the statistical analysis and helped write the paper. C.B.-R. was the hematopathologist who reviewed cases. G.G.-M. designed the study, analyzed data, contributed patients, and wrote the paper.
Fax: (713) 794-4297
- Issue published online: 5 SEP 2012
- Article first published online: 17 JAN 2012
- Manuscript Accepted: 8 NOV 2011
- Manuscript Revised: 21 SEP 2011
- Manuscript Received: 14 JUL 2011
- myelodysplastic syndrome;
- prognostic score;
- International Prognostic Scoring System
Although most patients with myelodysplastic syndrome (MDS) exhibit bone marrow hypercellularity, a subset of them present with a hypocellular bone marrow. Specific factors associated with poor prognosis have not been investigated in patients with hypocellular MDS.
The authors studied a cohort of 253 patients with hypocellular MDS diagnosed at The University of Texas MD Anderson Cancer Center between 1993 and 2007 and a cohort of 1725 patients with hyper-/normocellular MDS diagnosed during the same time period.
Patients with hypocellular MDS presented more frequently with thrombocytopenia (P < .019), neutropenia (P < .001), low serum β-2 microglobulin (P < .001), increased transfusion dependency (P < .001), and intermediate-2/high-risk disease (57% vs 42%, P = .02) compared with patients with hyper-/normocellular MDS. However, no difference in overall survival was observed between the 2 groups (P = .28). Multivariate analysis identified poor performance status (Eastern Cooperative Oncology Group ≥2), low hemoglobin (<10 g/dL), unfavorable cytogenetics (−7/7q or complex), increased bone marrow blasts (≥5%), and high serum lactate dehydrogenase (>600 IU/L) as adverse independent factors for survival.
A new prognostic model based on these factors was built that segregated patients into 3 distinct risk categories independent of International Prognostic Scoring System (IPSS) score. This model is independent from the IPSS, further refines IPSS-based prognostication, and may be used to develop of risk-adapted therapeutic approaches for patients with hypocellular MDS. Cancer 2012. © 2012 American Cancer Society.