Prevalence of breast cancer treatment sequelae over 6 years of follow-up§

The Pulling Through Study

Authors

  • Kathryn H. Schmitz PhD, MPH,

    Corresponding author
    1. University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center, Philadelphia, Pennsylvania
    • Division of Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 8th floor Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021
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    • Fax: (215) 898-7392

  • Rebecca M. Speck MPH,

    1. University of Pennsylvania Perelman School of Medicine, Abramson Cancer Center, Philadelphia, Pennsylvania
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  • Sheree A. Rye MAppSc,

    1. Queensland University of Technology, School of Public Health, Institute of Health and Biomedical Innovation, Brisbane, Australia
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  • Tracey DiSipio PhD,

    1. Queensland University of Technology, School of Public Health, Institute of Health and Biomedical Innovation, Brisbane, Australia
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  • Sandra C. Hayes PhD

    1. Queensland University of Technology, School of Public Health, Institute of Health and Biomedical Innovation, Brisbane, Australia
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  • The articles in this supplement were commissioned based on presentations and deliberations at a Roundtable Meeting on a Prospective Model of Care for Breast Cancer Rehabilitation, held February 24-25, 2011, at the American Cancer Society National Home Office, in Atlanta, Georgia.

  • The opinions or views expressed in this supplement are those of the authors, and do not necessarily reflect the opinions or recommendations of the editors or the American Cancer Society.

  • §

    Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms

  • A Prospective Surveillance Model for Rehabilitation for Women with Breast Cancer, Supplement to Cancer

Abstract

BACKGROUND:

There is a need to better describe and understand the prevalence of breast cancer treatment-related adverse effects amenable to physical therapy and rehabilitative exercise. Prior studies have been limited to single issues and lacked long-term follow-up. The Pulling Through Study provides data on prevalence of adverse effects in breast cancer survivors followed over 6 years.

METHODS:

A population-based sample of Australian women (n = 287) diagnosed with invasive, unilateral breast cancer was followed for a median of 6.6 years and prospectively assessed for treatment-related complications at 6, 12, and 18 months and 6 years after diagnosis. Assessments included postsurgical complications, skin or tissue reaction to radiation therapy, upper-body symptoms, lymphedema, 10% weight gain, fatigue, and upper-quadrant function. The proportion of women with positive indication for each complication and 1 or more complication was estimated using all available data at each time point. Women were only considered to have a specific complication if they reported the highest 2 levels of the Likert scale for self-reported issues.

RESULTS:

At 6 years after diagnosis, more than 60% of women experienced 1 or more side effects amenable to rehabilitative intervention. The proportion of women experiencing 3 or more side effects decreased throughout follow-up, whereas the proportion experiencing no side effects remained stable around 40% from 12 months to 6 years. Weight gain was the only complication to increase in prevalence over time.

CONCLUSIONS:

These data support the development of a multidisciplinary prospective surveillance approach for the purposes of managing and treating adverse effects in breast cancer survivors. Cancer 2012;118(8 suppl):. © 2012 American Cancer Society.

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