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Response to Letter to the Editor
Nilotinib, imatinib, and telomere homeostasis disruption in chronic myeloid leukemia†
Reply to nilotinib versus imatinib: Molecular mechanism(s) of its better efficacy
Article first published online: 25 APR 2012
Copyright © 2012 American Cancer Society
Volume 118, Issue 20, page 5183, 15 October 2012
How to Cite
Nicolini, F. E., Manley, P. W. and Brümmendorf, T. H. (2012), Nilotinib, imatinib, and telomere homeostasis disruption in chronic myeloid leukemia. Cancer, 118: 5183. doi: 10.1002/cncr.27481
- Issue published online: 5 OCT 2012
- Article first published online: 25 APR 2012
- Manuscript Accepted: 9 JAN 2012
- Manuscript Received: 8 JAN 2012
We demonstrated in a series of patients with late chronic phase (CP) chronic myeloid leukemia (CML) that nilotinib induces high levels of response with acceptable toxicities, and prolongs progression-free survival.1 Recently, Bakalova et al2 speculated on the role of telomerase activity (TA) in CML and its relationship with tyrosine kinase inhibitors (TKIs) such as imatinib and nilotinib. They hypothesize that differential effects of TKIs on TA play a role in the future use of TKIs in terms of choice and dose.
To date, this assumption seems speculative because any direct effect of TKIs on TA has never been demonstrated convincingly in vivo. Moreover, it remains controversial whether TA in CP CML is increased in breakpoint cluster region/-Abelson oncogene (BCR-ABL)-positive (BCR-ABL+) hematopoietic stem cells specifically at all, or simply reflects the increased cell cycle activity within the CD34-positive leukemic compartment typically assayed for TA.3 Furthermore, studies addressing effects of TKIs on BCR-ABL+ cells provided controversial results ranging from inhibition of TA to no effect whatsoever, and even to increased levels of TA observed under treatment.4 In addition, as the authors point out, the direct or indirect effects of TKIs on TA might also be dose dependent.2
Nevertheless, the association of telomerase up-regulation with CP CML progression to accelerated phase (AP) and/or blast crisis (BC) has been reported consistently.4 Furthermore, evidence has accumulated over the last 15 years regarding the correlation of dysfunctional telomeres with disease progression. Telomere length has been demonstrated to be significantly shortened both compared with age-adjusted controls as well as compared with BCR-ABL− T cells derived from the same patients.5 Accelerated telomere shortening has been correlated with disease stage (ie, CP > AP/BC), Hasford risk score, response to treatment, and (in patients with CP CML) with the duration until disease progression to AP/BC.4, 5 Based on these results, telomere length, at least in the context of intact cell cycle checkpoints, could represent a valuable prognostic and/or predictive biomarker for disease progression, response to TKIs, and potentially for maintenance of response upon cessation of TKI treatment.6 These questions are being addressed prospectively as part of a scientific subproject performed in patients with CP CML who are undergoing nilotinib as front-line treatment (the ENEST1st study).
In conclusion, increasing evidence points to a strong direct or indirect interaction between BCR-ABL activity and telomere maintenance in CML, which is most likely mediated via effects on TA. Whether this phenomenon could be used clinically as a predictive biomarker, and even for selection of individual TKIs most suitable for individual patients, remains to be demonstrated.
CONFLICT OF INTEREST DISCLOSURES
Dr. Manley is an employee of Novartis Pharma AG. The other authors made no disclosure.
- 1Expanding Nilotinib Access in Clinical Trials (ENACT): an open-label, multicenter study of oral nilotinib in adult patients with imatinib-resistant or imatinib-intolerant philadelphia chromosome-positive chronic myeloid leukaemia in the chronic phase. Cancer. 2012; 118: 118-126., , , et al.
- 2Nilotinib versus imatinib: molecular mechanism(s) of its better efficacy. Cancer. 2012; 118: 5180-5181., , .
- 3Telomere biology in normal and leukemic hematopoietic stem cells. Stem Cells. 2007; 25: 1853-1861., , , .
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- 5Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood. 2000; 95: 1883-1890., , , et al.
- 6Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010; 11: 1029-1035., , , et al.
Franck E. Nicolini MD, PhD*, Paul W. Manley MD, PhD, Tim H. Brümmendorf MD, * Hématologie Clinique 1G, Centre Hospitalier Lyon Sud, Pierre Bénite, France, Novartis Pharma AG, Basel, Switzerland, Medizinischen Klinik IV, Hämatologie und Onkologie, Universitätsklinikum Aachen, Aachen, Germany.