Association of the interval between endoscopies with gastric cancer stage at diagnosis in a region of high prevalence
Article first published online: 16 JUL 2012
Copyright © 2012 American Cancer Society
Volume 118, Issue 20, pages 4953–4960, 15 October 2012
How to Cite
Nam, J. H., Choi, I. J., Cho, S.-J., Kim, C. G., Jun, J. K., Choi, K. S., Nam, B.-H., Lee, J. H., Ryu, K. W. and Kim, Y.-W. (2012), Association of the interval between endoscopies with gastric cancer stage at diagnosis in a region of high prevalence. Cancer, 118: 4953–4960. doi: 10.1002/cncr.27495
- Issue published online: 5 OCT 2012
- Article first published online: 16 JUL 2012
- Manuscript Accepted: 18 JAN 2012
- Manuscript Revised: 21 DEC 2011
- Manuscript Received: 14 AUG 2011
- National Cancer Center, Korea. Grant Number: NCC 1010190
- gastric cancer;
- cancer stage;
- family history
Endoscopy screening in high-risk populations may reduce gastric cancer mortality by detecting cancer earlier. We evaluated the association between the interval between upper gastrointestinal endoscopies and the gastric cancer stage at diagnosis in patients from a region of high prevalence.
The study cohort consisted of 2485 patients diagnosed with gastric adenocarcinoma. We evaluated the effect on cancer stage of the interval between the endoscopy that was diagnostic for gastric cancer and the endoscopy preceding it. Patients were stratified into 7 groups: 1-, 2-, 3-, 4-, 5-, >5-year intervals and those who were never screened.
The risk of higher cancer stage at diagnosis increased by 23% per increase in interval length (odds ratio = 1.23, 95% confidence interval [CI] = 1.19-1.28). Compared to the never-screened, the odds ratio of having a higher stage of cancer decreased gradually from 0.53 (95% CI = 0.41-0.69) in the >5-year interval group to 0.31 (95% CI = 0.24-0.40) in the 1-year interval group. Compared to the 1-year interval group, the risk of advanced gastric cancer was increased in the 4- and 5-year, but not the 2- and 3-year, interval groups. However, patients with a family history of gastric cancer were more likely to have a higher stage at diagnosis if they had a 3-year interval rather than a 1-year interval.
A significant benefit in cancer stage at diagnosis was observed in all interval groups compared to never-screened. Endoscopy intervals of 3 years or less showed similar benefits, but family members of gastric cancer patients may benefit from intervals of under 3 years. Cancer 2012. © 2012 American Cancer Society.