Original Article

Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk †‡§

  1. Meredith S. Shiels PhD, MHS1,¶,*,
  2. Eric A. Engels MD, MPH1,
  3. Jianxin Shi PhD2,
  4. Maria Teresa Landi MD, PhD3,
  5. Demetrius Albanes MD4,
  6. Nilanjan Chatterjee PhD2,
  7. Stephen J. Chanock MD5,
  8. Neil E. Caporaso MD3,
  9. Anil K. Chaturvedi PhD1

Article first published online: 8 OCT 2012

DOI: 10.1002/cncr.27605

Issue

Cancer

Cancer

Volume 118, Issue 22, pages 5630–5636, 15 November 2012

Additional Information

How to Cite

Shiels, M. S., Engels, E. A., Shi, J., Landi, M. T., Albanes, D., Chatterjee, N., Chanock, S. J., Caporaso, N. E. and Chaturvedi, A. K. (2012), Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk . Cancer, 118: 5630–5636. doi: 10.1002/cncr.27605

Author Information

  1. 1

    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland

  2. 2

    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland

  3. 3

    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland

  4. 4

    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland

  5. 5

    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland

  1. Fax: (301) 402-0817

*Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7059, Rockville, MD 20892

  1. †

    For the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we thank Drs. Christine Berg and Philip Prorok, Division of Cancer Prevention, National Cancer Institute (NCI); the Screening Center investigators and staff of the PLCO Cancer Screening Trial; Mr. Tom Riley and staff, Information Management Services, Inc.; Ms. Barbara O'Brien and staff, Westat, Inc.; Mr. Tim Sheehy and staff, DNA Extraction and Staging Laboratory, Science Applications International Corporation (SAIC)-Frederick, Inc.; and Ms. Jackie King and staff, BioReliance, Inc. Most important, we acknowledge the study participants for their contributions to making this study possible.

  2. ‡

    For the NCI genome-wide association study, we thank the participants and collaborators of the Environment and Genetics in Lung Cancer Etiology (EAGLE), Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC), PLCO, and Cancer Prevention Study-II (CPS-II) Nutrition Cohort studies; the staff of the Core Genotyping Facility—specifically Amy Hutchinson, Aurelie Vogt, Kevin Jacobs, and Zhaoming Wang; the National Center for Biotechnology for assistance with data cleaning; Justin Paschall and Mike Feolo for data manipulation; and Adam Risch, Bill Wheeler, and Sihui Zhao of Information Management Services, Inc. for database support. *This article is US Government work and, as such, is in the public domain in the United States of America.

  3. §

    This article is US Government work and, as such, is in the public domain in the United States of America.

  4. Fax: (301) 402-0817

Publication History

  1. Issue published online: 30 OCT 2012
  2. Article first published online: 8 OCT 2012
  3. Manuscript Accepted: 22 MAR 2012
  4. Manuscript Revised: 20 MAR 2012
  5. Manuscript Received: 13 JAN 2012

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