How is a molecular polymorphism defined?

Authors

  • Verena Schildgen,

    Dr. rer. nat.
    1. Hospital of the City of Cologne, University Hospital Witten-Herdecke, Institute of Pathology, Cologne, Germany
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  • Oliver Schildgen

    Prof. Dr. rer. nat., Corresponding author
    1. Hospital of the City of Cologne, University Hospital Witten-Herdecke, Institute of Pathology, Cologne, Germany
    • Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Klinikum der Privaten Universität Witten/Herdecke Institut für Pathologie, Ostmerheimer Str. 200, D-51109 Köln, Germany; Fax: (011) 49 (0) 221-8907-3542

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Abstract

In this commentary, the authors address the question of how molecular polymorphisms are defined. Despite an overwhelming amount of literature reporting on single-nucleotide polymorphisms, there is still no harmonized definition of this term, which the authors believe is not acceptable in the area of personalized medicine.

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