Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Authors


  • Presented at the 8th International Conference on Head and Neck Cancer; July 21-25, 2012; Toronto, Ontario, Canada.

  • We thank Ms. A. Tsuyuzaki and Ms. K. Miwa (Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan) and Kei Sakuma (Department of Pathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan) for the excellent technical assistance. We also thank Nobuhiko Kurita, Toru Sasaki, Kenji Kondo, Takashi Sakamoto, Kenta Watanabe, Asayo Furukawa, Hironobu Nishijima, Shinichi Ishimoto, Satoshi Takeuchi, Makoto Kinoshita, Chie Motoyama, and Ryosuke Murakami for their help in preparing sections.

Abstract

BACKGROUND

The prevalence and prognostic value of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) in Japan has not been evaluated.

METHODS

Over a 12-year period, the authors used immunohistochemistry to evaluate the expression of p16 (a cyclin-dependent kinase inhibitor and tumor suppressor) in samples from 173 patients with OPSCC at a single institution and to determine its prevalence and influence on disease prognosis.

RESULTS

The prevalence of p16-positive OPSCC was 33.7% in tonsillar carcinoma, 28.6% in tongue base carcinoma, 0% in posterior wall carcinoma, and 18.8% in soft palate carcinoma. The prevalence of p16-positive OPSCC tumors increased from 15.2% during 2000 to 2003 up to 33.3% during 2008 to 2011; during the same periods, among nonsmokers, the prevalence of p16-positive OPSCC tumors increased from 21.2% to 27.8%; and, among nondrinkers, prevalence increased from 6.1% to 25%. Multivariate analysis identified p16 expression and alcohol consumption as significant, independent prognostic markers of OPSCC.

CONCLUSIONS

The current results suggest that the incidence of human papillomavirus-related OPSCC in Japan is increasing and indicate that p16 expression and alcohol consumption may be significant prognostic markers of survival for patients with OPSCC in Japan. Cancer 2013;119:2005–2011. © 2013 American Cancer Society.

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