See related editorial on pages 2953–2955, this issue.
Individual and geographic disparities in human papillomavirus types 16/18 in high-grade cervical lesions
Associations with race, ethnicity, and poverty
Article first published online: 9 MAY 2013
Copyright © 2013 American Cancer Society
Volume 119, Issue 16, pages 3052–3058, 15 August 2013
How to Cite
Niccolai, L. M., Russ, C., Julian, P. J., Hariri, S., Sinard, J., Meek, J. I., McBride, V., Markowitz, L. E., Unger, E. R., Hadler, J. L. and Sosa, L. E. (2013), Individual and geographic disparities in human papillomavirus types 16/18 in high-grade cervical lesions. Cancer, 119: 3052–3058. doi: 10.1002/cncr.28038
We acknowledge the contributions of Martin Steinau, PhD, from the Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC), and Suzanne E. Powell, MPH, from the Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, of the CDC.
- Issue published online: 2 AUG 2013
- Article first published online: 9 MAY 2013
- Manuscript Accepted: 1 FEB 2013
- Manuscript Revised: 29 JAN 2013
- Manuscript Received: 29 DEC 2012
- human papillomavirus;
- human papillomavirus types;
- high-grade cervical lesions;
- health disparities;
Current vaccines protect against 2 human papillomavirus (HPV) types, HPV 16 and 18, which are associated with 70% of cervical cancers and 50% of high-grade cervical lesions. HPV type distribution was examined among women with high-grade lesions by individual and area-based measures of race, ethnicity, and poverty.
This analysis included 832 women aged 18 to 39 years reported to a surveillance registry in Connecticut during 2008 to 2010. Diagnostic specimens were obtained for HPV DNA testing. Individual measures were obtained from surveillance reports, medical records, and patient interviews. Cases were geocoded to census tracts and linked to area-based measures of race, ethnicity, and poverty. Statistical analysis included use of generalized estimating equations.
Overall, 44.8% of women had HPV 16/18. In a multivariate model controlled for confounding by age and diagnosis grade, black race (adjusted prevalence ratio [aPR] = 0.54, 95% confidence interval [CI] = 0.34-0.88), Hispanic ethnicity (aPR = 0.59, 95% CI = 0.40-0.88), and higher area-based poverty (aPR = 0.59, 95% CI = 0.40-0.87) were associated with a lower likelihood of HPV 16/18 positivity. Black and Hispanic women were less likely to have HPV 16/18 than white women across all levels of area-based measures.
Black race, Hispanic ethnicity, and higher area-based poverty are salient predictors of lower HPV 16/18 positivity among women with high-grade cervical lesions. These data suggest that HPV vaccines might have lower impact among black and Hispanic women and those living in high poverty areas. These findings have implications for vaccine impact monitoring, vaccination programs, and new vaccine development. Cancer 2013;119:3052—3058. © 2013 American Cancer Society.