The first 2 authors contributed equally to this work.
Near-infrared fluorescence-guided resection of colorectal liver metastases
Version of Record online: 21 JUN 2013
© 2013 American Cancer Society
Volume 119, Issue 18, pages 3411–3418, 15 September 2013
How to Cite
van der Vorst, J. R., Schaafsma, B. E., Hutteman, M., Verbeek, F. P. R., Liefers, G.-J., Hartgrink, H. H., Smit, V. T. H. B. M., Löwik, C. W. G. M., van de Velde, C. J. H., Frangioni, J. V. and Vahrmeijer, A. L. (2013), Near-infrared fluorescence-guided resection of colorectal liver metastases. Cancer, 119: 3411–3418. doi: 10.1002/cncr.28203
Clinical trial registered with The Netherlands Trial Register (NTR2213).
- Issue online: 4 SEP 2013
- Version of Record online: 21 JUN 2013
- Manuscript Accepted: 13 MAY 2013
- Manuscript Revised: 24 APR 2013
- Manuscript Received: 29 MAR 2013
- image-guided surgery;
- liver neoplasms;
- colorectal cancer;
- indocyanine green;
The fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. The objectives of this study were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize dose and timing, and to determine the mechanism of contrast agent accumulation.
The high tissue penetration of near-infrared (NIR) light was exploited by use of the FLARE (Fluorescence-Assisted Resection and Exploration) image-guided surgery system and the NIR fluorophore indocyanine green in a clinical trial of 40 patients undergoing hepatic resection for colorectal cancer metastases.
A total of 71 superficially located (< 6.2 mm beneath the liver capsule) colorectal liver metastases were identified and resected using NIR fluorescence imaging. Median tumor-to-liver ratio was 7.0 (range, 1.9-18.7) and no significant differences between time points or doses were found. Indocyanine green fluorescence was seen as a rim around the tumor, which is shown to be entrapment around cytokeratin 7–positive hepatocytes compressed by the tumor. Importantly, in 5 of 40 patients (12.5%, 95% confidence interval = 5.0-26.6), additional small and superficially located lesions were detected using NIR fluorescence, and were otherwise undetectable by preoperative computed tomography, intraoperative ultrasound, visual inspection, and palpation.
NIR fluorescence imaging, even when used with a nontargeted, clinically available NIR fluorophore, is complementary to conventional imaging and able to identify missed lesions by other modalities. Cancer 2013;119:3411–8. © 2013 American Cancer Society.