Adenocarcinoma of the small intestine arising in crohn's disease: Demonstration of a tumor-associated antigen in invasive and intraepithelial components

Authors

  • Robert D. Newman MD,

    Instructor, Corresponding author
    1. Clinical Pathology, College of Physicians and Surgeons and Department of Pathology, Greenwich Hospital, Greenwich, CT
    2. Department of Pathology, Greenwich Hosopital, Greenwich, CT, New York, NY
    3. Departments of Surgery and Pathology, Columbia University College of Physicians and Surgeons, New York, NY
    • Department of Pathology, Greenwich Hospital, Greenwich, CT 06830
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  • Sidney J. Bennett PhD,

    Research Associate
    1. Department of Surgery, College of Physicians and Surgeons
    2. Department of Pathology, Greenwich Hosopital, Greenwich, CT, New York, NY
    3. Departments of Surgery and Pathology, Columbia University College of Physicians and Surgeons, New York, NY
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  • Robert R. Pascal MD

    Associate Professor of Pathology
    1. College of Physicians and Surgeons
    2. Department of Pathology, Greenwich Hosopital, Greenwich, CT, New York, NY
    3. Departments of Surgery and Pathology, Columbia University College of Physicians and Surgeons, New York, NY
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Abstract

A segment of small intestine surgically removed from a man with intestinal obstruction was found to have coexisting regional enteritis and an invasive adenocarcinoma associated with an area of intraepithelial neoplasia. The cells of the adenocarcinoma and the intraepithelial neoplasia contained a tumor-associated surface antigen capable of reacting with an antiserum prepared against a colonic carcinoma. The importance of thorough sampling of specimens of regional enteritis in accurate reporting of the incidence of carcinoma is stressed, as is the use of immunohistologic techniques as an adjunct to the morphologic diagnosis of preinvasive neoplasia.

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