Primary biphasic lymphoplasmacytic lymphoma of the lung: A mucosa-associated lymphoid tissue lymphoma with compartmentalization of plasma cells in the lung and lymph nodes

Authors

  • R. Chetty FFPath,

    1. Departments of Anatornical Pathology, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
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  • P. M. Close MRCPath,

    Corresponding author
    1. Departments of Anatornical Pathology, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    • Department of Anatomical Pathology, University of Cape Town Medical School, Anzio Road, Observatory 7925, Cape Town, South Africa
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  • A. H. Timme MMed,

    1. Departments of Anatornical Pathology, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
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  • P. A. Willcox MRCP,

    1. Departments of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
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  • M. D. Forder MMedPath

    1. Departments of Anatornical Pathology, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
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Abstract

A primary mucosa-associated lymphoid tissue lymphoma of the lung in a 27-year-old man was found. The tumor was composed mainly of centrocyte-like cells and plasma cells. These two components were demarcated sharply from each other, resulting in a zoning or biphasic pattern. This characteristic pattern also was present in the involved regional lymph nodes. Monoclonality of tumor cells was shown immunohistochemically and by in situ hybridization techniques. This article also highlights the use of in situ hybridization in detecting light chain mRNA in paraffin sections.

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