Visiting Fellow from the Department of Obstetrics and Gynecology, University of the Philippines, Manila, the Philippines, supported by the Ronpaku Program of the Japan Society for the Promotion of Science, Tokyo, Japan.
Immunohistochemical demonstration of elevated expression of epidermal growth factor receptor in the neoplastic changes of cervical squamous epithelium
Version of Record online: 2 AUG 2010
Copyright © 1992 American Cancer Society
Volume 69, Issue 5, pages 1182–1187, 1 March 1992
How to Cite
Maruo, T., Yamasaki, M., Ladines-Llave, C. A. and Mochizuki, M. (1992), Immunohistochemical demonstration of elevated expression of epidermal growth factor receptor in the neoplastic changes of cervical squamous epithelium. Cancer, 69: 1182–1187. doi: 10.1002/cncr.2820690519
- Issue online: 2 AUG 2010
- Version of Record online: 2 AUG 2010
- Manuscript Accepted: 24 MAY 1991
- Japanese Ministry of Education, Science and Culture. Grant Numbers: 61570796, 0267074
To evaluate epidermal growth factor (EGF) receptor expression in the neoplastic process of squamous cell epithelium of the uterine cervix, normal, premalignant, and malignant cervical tissues were examined for the presence of EGF receptor by the avidin-biotin immunoperoxidase techniques with a monoclonal antibody to EGF receptor, Although normal cervical epithelium did not show appreciable staining for EGF receptor, predominant staining for the receptor was observed in most dys-plastic epithelia and carcinomas in situ. In invasive squamous carcinoma, there was a great difference in the immunohistochemically detected levels of EGF receptor among the histologic cell types. Large cell nonkeratinizing carcinoma and its keratinizing counterpart contained high levels of EGF receptor; small cell nonkeratinizing carcinoma lacked immunostainable EGF receptor, These results suggest that the elevated expression of EGF receptor may be involved in the initial stage of tumori-genesis of cervical squamous epithelium and that EGF receptor expression may be related to the differentiation or dedifferentiation of cervical squamous carcinoma cells.