Because all information from the Surveillance, Epidemiology, and End Results (SEER) Program data is deidentified, informed consent by the study participants and approval of an ethics committee were unnecessary to perform the analyses in this study.
Racial disparities in cervical cancer survival over time
Article first published online: 31 JUL 2013
Copyright © 2013 American Cancer Society
Volume 119, Issue 20, pages 3644–3652, 15 October 2013
How to Cite
Rauh-Hain, J. A., Clemmer, J. T., Bradford, L. S., Clark, R. M., Growdon, W. B., Goodman, A., Boruta, D. M., Schorge, J. O. and del Carmen, M. G. (2013), Racial disparities in cervical cancer survival over time. Cancer, 119: 3644–3652. doi: 10.1002/cncr.28261
An abstract of this manuscript was accepted at the 2013 American Society of Clinical Oncology Annual Meeting.
- Issue published online: 4 OCT 2013
- Article first published online: 31 JUL 2013
- Manuscript Accepted: 28 MAY 2013
- Manuscript Revised: 4 MAY 2013
- Manuscript Received: 12 APR 2013
- cervical cancer;
- African American;
The purpose of this study is to examine changes over time in survival for African American (AA) and white women diagnosed with cervical cancer (CC).
Surveillance, Epidemiology, and End Results (SEER) Program data from 1985 to 2009 were used for this analysis. Racial differences in survival were evaluated between African American (AA) and white women. Kaplan-Meier and Cox proportional hazards survival methods were used to assess differences in survival by race at 5-year intervals.
The study sample included 23,368 women, including 3886 (16.6%) who were AA and 19,482 (83.4%) who were white. AA women were older (51.4 versus 48.9 years; P < .001) and had a higher rate of regional (38.3% versus 31.8%; P < .001) and distant metastasis (10.7% versus 8.7%; P < .001). AA less frequently received cancer-directed surgery (32.4% versus 46%; P < .001), and more frequently radiotherapy (36.3% versus 26.4%; P < .001). Overall, AA women had a hazard ratio (HR) of 1.41 (95% confidence interval = 1.32-1.51) of cervical cancer (CC) mortality compared with whites. Adjusting for SEER registry, marital status, stage, age, treatment, grade, and histology, AA women had an HR of 1.13 (95% confidence interval = 1.05-1.22) of CC-related mortality. After adjusting for the same variables, there was a significant difference in CC-specific mortality between 1985 to 1989 and 1990 to 1994, but not after 1995.
After adjusting for race, SEER registry, marital status, stage, age, treatment, grade, and histology, there was a significant difference in CC-specific mortality between 1985 to 1989 and 1990 to 1994, but not after 1995. Cancer 2013;119:3644–3652. © 2013 American Cancer Society.