We thank Sharon Naron for her editorial assistance.
Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia
Article first published online: 30 DEC 2013
© 2013 American Cancer Society
Volume 120, Issue 7, pages 955–962, 1 April 2014
How to Cite
Lim, J. Y.-S., Bhatia, S., Robison, L. L. and Yang, J. J. (2014), Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia. Cancer, 120: 955–962. doi: 10.1002/cncr.28531
- Issue published online: 18 MAR 2014
- Article first published online: 30 DEC 2013
- Manuscript Accepted: 20 NOV 2013
- Manuscript Revised: 1 NOV 2013
- Manuscript Received: 30 JUL 2013
Although the cure rates of childhood acute lymphoblastic leukemia (ALL) have improved dramatically in the past 40 years, not all children have benefited equally from this impressive progress. Racial and ethnic disparities in the incidence and treatment outcome of childhood ALL persist, with Hispanic children having an elevated risk of developing ALL and one of the lowest survival rates after ALL therapy. A critical barrier to progress is the lack of an understanding of the causes of ALL disparities, particularly racial and ethnic differences in ALL biology. In this review, the authors summarize the current knowledge on population variation in childhood ALL incidence and treatment outcome, discuss the contributing genetic and nongenetic variables, and highlight possible therapeutic interventions to mitigate disparities in ALL. Cancer 2014;120:955–962. © 2013 American Cancer Society.