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Many lifestyle factors, such as diet, physical activity, smoking, alcohol consumption, and adiposity, are modifiable, and there is great interest whether changing these factors could have potential preventive benefits in those without colorectal cancer and adjuvant benefits for those with the disease. A recent study demonstrates that individual exposures and healthier composite lifestyle are associated with improved overall and/or cardiovascular mortality, which highlights to clinicians that colorectal cancer survivors are at risk for other comorbidities that are associated with increased mortality.